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Titolo:
Acyl-coenzyme A : cholesteryl acyltransferase 2
Autore:
Joyce, C; Skinner, K; Anderson, RA; Rudel, LL;
Indirizzi:
Wake7Forest Univ, Sch Med, Dept Pathol Comparat Med, Winston Salem, NC 2715 Wake Forest Univ Winston Salem NC USA 27157 t Med, Winston Salem, NC 2715 Wake Forest Univ, Sch Med, Dept Internal Med, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA
Titolo Testata:
CURRENT OPINION IN LIPIDOLOGY
fascicolo: 2, volume: 10, anno: 1999,
pagine: 89 - 95
SICI:
0957-9672(199904)10:2<89:AA:CA2>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY ATHEROSCLEROSIS; AFRICAN-GREEN MONKEYS; LOW-DENSITY LIPOPROTEINS; MESSENGER-RNA LEVELS; APO-B SECRETION; NONHUMAN-PRIMATES; MOLECULAR-CLONING; HEPG2 CELLS; FUNCTIONAL EXPRESSION; APOLIPOPROTEIN-B;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Rudel, LL WakeSalem,t Univ, Sch Med, Dept Pathol Comparat Med, Med Ctr Blvd, Winston Wake Forest Univ Med Ctr Blvd Winston Salem NC USA 27157 Winston
Citazione:
C. Joyce et al., "Acyl-coenzyme A : cholesteryl acyltransferase 2", CURR OP LIP, 10(2), 1999, pp. 89-95

Abstract

In addition to acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT1), an enzyme in the endoplasmic reticulum of cells found ubiquitously throughout the body, data recently obtained in at least three mammalian species, including nonhuman primates, mice and humans, demonstrate the presence of an additional ACAT (EC 2.1.3.26), termed ACAT2, which is localized to the endoplasmic reticulum of liver and intestine. Data suggest that ACAT2 may be the enzyme responsible for cholesteryl ester secretion into apolipoprotein B-containing lipoproteins. We have hypothesized that oversecretion of cholesterylesters produced by the action of hepatic ACAT2 could account for the increased atherogenicity associated with cholesteryl ester-enriched LDL in nonhuman primates. In such cases, ACAT2 is an appealing target for therapy to reduce coronary heart disease. Curr Opin Lipidol 10:89-95. (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 09:41:12