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Titolo:
Predicting response to clozapine - Status of current research
Autore:
Hu, RJ; Malhotra, AK; Pickar, D;
Indirizzi:
Stanford Univ, Sch Med, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 Univ, Sch Med, Stanford, CA 94305 USA
Titolo Testata:
CNS DRUGS
fascicolo: 4, volume: 11, anno: 1999,
pagine: 317 - 326
SICI:
1172-7047(199904)11:4<317:PRTC-S>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-HT2A RECEPTOR GENE; DIFFERENT ETHNIC-GROUPS; INDUCED AGRANULOCYTOSIS; SCHIZOPHRENIC-PATIENTS; CLINICAL-RESPONSE; WEIGHT-GAIN; ALLELIC VARIATION; ANTIPSYCHOTIC-DRUGS; TREATED PATIENTS; CODING REGIONS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
80
Recensione:
Indirizzi per estratti:
Indirizzo: Hu, RJ Stanford Univ, Sch Med, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 ch Med, Stanford, CA 94305 USA
Citazione:
R.J. Hu et al., "Predicting response to clozapine - Status of current research", CNS DRUGS, 11(4), 1999, pp. 317-326

Abstract

Clozapine, the prototype for the new generation of atypical antipsychotics, has demonstrated efficacy in treating schizophrenia, particularly in patients with symptoms that are refractory to traditional antipsychotics. Unfortunately, clozapine is associated with agranulocytosis in a small but significant minority of patients. Reliable predictors of response, whether therapeutic or adverse, to clozapine would assist clinicians in using this drug more effectively. This article reviews some of the proposed mechanisms of action of clozapine, and surveys current research on potential predictors of favourable and adverse outcomes to clozapine treatment. Demographic factors, plasma clozapine concentrations, neurochemical measures at baseline, response to pharmacological challenges, neuroimaging and molecular genetics have all been considered. Although conclusive, sensitive and specific predictors of response to clozapine have yet to be identified, significant associations have been found for predictors of both favourable response and adverse effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 12:18:43