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Titolo:
Double-phase Tc-99m sestamibi scintimammography to assess angiogenesis andP-glycoprotein expression in patients with untreated breast cancer
Autore:
Yoon, JH; Bom, HS; Song, HC; Lee, JH; Jaegal, YJ;
Indirizzi:
Chonnam Univ Hosp, Dept Nucl Med, Kwangju 501757, South Korea Chonnam UnivHosp Kwangju South Korea 501757 Kwangju 501757, South Korea Chonnam Univ Hosp, Dept Surg, Kwangju 501757, South Korea Chonnam Univ Hosp Kwangju South Korea 501757 Kwangju 501757, South Korea Chonnam Univ Hosp, Dept Pathol, Kwangju 501757, South Korea Chonnam Univ Hosp Kwangju South Korea 501757 Kwangju 501757, South Korea
Titolo Testata:
CLINICAL NUCLEAR MEDICINE
fascicolo: 5, volume: 24, anno: 1999,
pagine: 314 - 318
SICI:
0363-9762(199905)24:5<314:DTSSTA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR ANGIOGENESIS; TECHNETIUM-99M-SESTAMIBI; LESIONS;
Keywords:
angiogenesis; breast cancer; double-phase; Tc-99m sestamibi scintimammography; P-glycoprotein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Bom, HS Chonnam Univ Hosp, Dept Nucl Med, Kwangju 501757, South Korea Chonnam Univ Hosp Kwangju South Korea 501757 501757, South Korea
Citazione:
J.H. Yoon et al., "Double-phase Tc-99m sestamibi scintimammography to assess angiogenesis andP-glycoprotein expression in patients with untreated breast cancer", CLIN NUCL M, 24(5), 1999, pp. 314-318

Abstract

This study evaluated the relation of Tc-99m sestamibi (MIBI) uptake and washout in untreated breast cancer with immunohistochemically determined angiogenesis and P-glycoprotein expression. Thirty-one patients with untreated breast cancer were studied prospectively. Tc-99m MIBI scintigraphy and immunohistochemical analyses of angiogenesis and P-glycoprotein expression wereused to evaluate surgically removed tumor tissues. Anterior and both lateral planar images were acquired 10 and 180 minutes after intravenous injection of 740 MBq (20 mCi) Tc-99m MIBI. The tumor-to-normal breast ratio (T:N) and washout index (early T:N - late T:N divided by early T:N) were calculated. A significant correlation was found between angiogenesis and T:N at early and late images. Pearson's correlation coefficients and probability values were r = 0.54, P = 0.002 at early images and r = 0.47, P = 0.008 at lateimages. The T:N of both early and late images were not different among different groups of P-glycoprotein expression (P = 0.367 and P = 0.113, respectively), although the washout index was significantly different among the groups (P = 0.001), A strong correlation was found between the washout indexand P-glycoprotein expression (r = 0.67, P < 0.01). Double-phase scintimammography to assess the early tumoral uptake and washout of Tc-99m MIBI can be used as a simple functional test for in vivo imaging of tumoral angiogenesis and P-glycoprotein expression in patients with untreated breast cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 10:21:52