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Titolo:
Haemorrhagic cystitis: Incidence and risk factors in a transplant population using hyperhydration
Autore:
Trotman, J; Nivison-Smith, I; Dodds, A;
Indirizzi:
St Vincents Hosp, Dept Haematol, Darlinghurst, NSW 2010, Australia St Vincents Hosp Darlinghurst NSW Australia 2010 rst, NSW 2010, Australia
Titolo Testata:
BONE MARROW TRANSPLANTATION
fascicolo: 8, volume: 23, anno: 1999,
pagine: 797 - 801
SICI:
0268-3369(199904)23:8<797:HCIARF>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; INDUCED HEMORRHAGIC CYSTITIS; HIGH-DOSE CHEMOTHERAPY; BK VIRURIA; MESNA; COMPLICATIONS; ASSOCIATION; PREVENTION;
Keywords:
haemorrhagic cystitis; hyperhydration; cyclophosphamide; allogeneic transplantation; immune suppression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Dodds, A Staliacents Hosp, Dept Haematol, Victoria St, Darlinghurst, NSW 2010, Austr St Vincents Hosp Victoria St Darlinghurst NSW Australia 2010 ustr
Citazione:
J. Trotman et al., "Haemorrhagic cystitis: Incidence and risk factors in a transplant population using hyperhydration", BONE MAR TR, 23(8), 1999, pp. 797-801

Abstract

Haemorrhagic cystitis (HC) is the syndrome of haematuria and symptoms of lower urinary tract irritability in the absence of bacterial infection. We report a low incidence of HC (18.2%) in 681 haemopoietic stem cell transplant patients, using a prophylactic regimen of hyperhydration and forced diuresis. The incidence of grade 3-4 disease is 3.4%. There was a marked difference in incidence between allogeneic and autologous transplant populations, 24.2% vs 3.5% (P < 0.0005). Busulphan conditioning, acute GVHD, interstitial pneumonitis and use of methotrexate and cyclosporin immune suppression were associated with significantly increased incidence of HC in the allogeneic population. This may reflect the numerous factors that contribute to the greater immunosuppression and consequent increased risk for HC in allogeneic transplantation.

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Documento generato il 08/04/20 alle ore 12:06:15