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Titolo:
Effect of catecholamine depletion on lithium-induced long-term remission of bipolar disorder
Autore:
Anand, A; Darnell, A; Miller, HL; Berman, RM; Cappiello, A; Oren, DA; Woods, SW; Charney, DS;
Indirizzi:
Connecticut VA Hlth Care Syst, W Haven, CT 06516 USA Connecticut VA Hlth Care Syst W Haven CT USA 06516 W Haven, CT 06516 USA Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA Yale Univ New Haven CT USA iv, Sch Med, Dept Psychiat, New Haven, CT USA Connecticut Mental Hlth Ctr, New Haven, CT USA Connecticut Mental Hlth Ctr New Haven CT USA Hlth Ctr, New Haven, CT USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 8, volume: 45, anno: 1999,
pagine: 972 - 978
SICI:
0006-3223(19990415)45:8<972:EOCDOL>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID; RECEPTOR-BINDING; HEALTHY-SUBJECTS; METABOLITES; SYSTEMS; DEPRESSION; MECHANISMS; SEROTONIN; CARBONATE; MANIA;
Keywords:
bipolar disorder; mania; depression; dopamine; catecholamines; alpha-methylparatyrosine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Anand, A Connecticut VA Hlth Care Syst, W Haven, CT 06516 USA Connecticut VA Hlth Care Syst W Haven CT USA 06516 CT 06516 USA
Citazione:
A. Anand et al., "Effect of catecholamine depletion on lithium-induced long-term remission of bipolar disorder", BIOL PSYCHI, 45(8), 1999, pp. 972-978

Abstract

Background: This study investigated the effects of catecholamine depletionwith alpha-methylparatyrosine (AMPT) on mood indices in. patients with bipolar disorder who were in long-term remission with lithium therapy. Methods: Eight subjects with DSM-IV bipolar disorder currently in remission for >3 months on lithium were included in the study. Subjects were given either AMPT or placebo, in a randomized double-blind manner, in two test sessions of 4 days each. Results: Subjects did not have arty significant changes in mood during AMPT or placebo administration; however, 24-48 hours after the last active AMPT dose subjects had a transient I-elapse of hypomanic symptoms. Relapse of hypomanic symptoms did not correlate with increases in serum levels of homovanillic acid or 3-methoxy-4-hydroxyphenylglycol. Conclusions: These findings suggest that the mechanism of prevention of manic relapse by long-term lithium therapy may be dependent on stability of the catecholamine system. (C) 1999 Society of Biological Psychiatry.

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Documento generato il 18/01/20 alle ore 13:14:23