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Titolo:
Identity of the F52F12.1 gene product in Caenorhabditis elegans as an organic cation transporter
Autore:
Wu, X; Fei, YJ; Huang, W; Chancy, C; Leibach, FH; Ganapathy, V;
Indirizzi:
Med Coll Georgia, Dept Biochem & Mol Biol, Augusta, GA 30912 USA Med Coll Georgia Augusta GA USA 30912 m & Mol Biol, Augusta, GA 30912 USA Med Coll Georgia, Dept Anat & Cell Biol, Augusta, GA 30912 USA Med Coll Georgia Augusta GA USA 30912 & Cell Biol, Augusta, GA 30912 USA
Titolo Testata:
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
fascicolo: 1, volume: 1418, anno: 1999,
pagine: 239 - 244
SICI:
0005-2736(19990414)1418:1<239:IOTFGP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
FUNCTIONAL EXPRESSION; CARNITINE TRANSPORTER; MOLECULAR-CLONING; MECHANISMS; KIDNEY; ANIONS; OCTN2;
Keywords:
organic cation transporter; primary structure; gene structure; drug transport; (Caenorhabditis elegans);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Ganapathy, V Med Coll Georgia, Dept Biochem & Mol Biol, Augusta, GA 30912 USA Med Coll Georgia Augusta GA USA 30912 Augusta, GA 30912 USA
Citazione:
X. Wu et al., "Identity of the F52F12.1 gene product in Caenorhabditis elegans as an organic cation transporter", BBA-BIOMEMB, 1418(1), 1999, pp. 239-244

Abstract

We describe here the cloning and functional characterization of an organiccation transporter from Caenorhabditis elegans (CeOCT1). The CeOCT1 cDNA is 1826 bp long and codes for a protein of 568 amino acids. The oct1 gene issimilar to 3.2 kb in size and consists of 12 exons. The location of this gene corresponds to the F52F12.1 gene locus on chromosome I. The predicted protein contains 12 putative transmembrane domains. It exhibits significant homology to mammalian OCTs. When expressed in mammalian cells, CeOCT1 induces the transport of the prototypical organic cation tetraethylammonium. TheMichaelis-Menten constant for this substrate is 80 +/- 16 mu M. The substrate specificity of CeOCT1 is broad. This represents the first report on thecloning and functional characteristics of an organic cation transporter from C. elegans. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:14:25