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Titolo:
Ultrastructure of the hydrophobic gastric surfactant barrier in the dog
Autore:
Ethell, MT; Hodgson, DR; Hills, BA;
Indirizzi:
Univ Sydney, Vet Ctr, Camden, NSW 2570, Australia Univ Sydney Camden NSW Australia 2570 et Ctr, Camden, NSW 2570, Australia
Titolo Testata:
AUSTRALIAN VETERINARY JOURNAL
fascicolo: 4, volume: 77, anno: 1999,
pagine: 240 - 244
SICI:
0005-0423(199904)77:4<240:UOTHGS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUCOSAL BARRIER; ASPIRIN; RAT; PHOSPHATIDYLCHOLINE; PROSTAGLANDIN-E2; STOMACH; INJURY; LUMEN; ACID;
Keywords:
dog; gastric surfactant; gastric mucosal barrier; surface-active phospholipid; hydrophobic barrier;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Ethell, MT Massey Univ, Inst Vet Anim & Biomed Sci, Palmerston North, New Zealand Massey Univ Palmerston North New Zealand North, New Zealand
Citazione:
M.T. Ethell et al., "Ultrastructure of the hydrophobic gastric surfactant barrier in the dog", AUST VET J, 77(4), 1999, pp. 240-244

Abstract

Objectives To confirm the hydrophobicity of the luminal surface of the canine stomach and to elucidate the ultrastructure of the lining imparting that property. Design and procedures Gastric and duodenal mucosal samples from eight dogswere collected immediately after euthanasia and subjected to contact anglemeasurement using a goniometer. Other samples were examined by electron microscopy following a fixation procedure known to preserve phospholipids andoligolamellar structures. Results Contact angles for the canine gastric mucosal surface (85.1 +/- 5.5) were significantly greater (P < 0.0001) than for the duodenum (24.0 +/- 1.7). Electron microscopy revealed the existence of surfactant as abundant osmiophilic phospholipid material within the gastric and duodenal mucosae. Conclusion We have confirmed the hydrophobic nature of the canine gastric mucosa whereas the luminal surface of the duodenum is hydrophilic. We propose that the water-repellent nature of the canine gastric lining contributesto the 'gastric mucosal barrier' and is imparted by an oligolamellar layerof surface-active phospholipid ('gastric surfactant') adsorbed to the surface. Both gastric and duodenal mucosae may also utilise phospholipids as anintercellular defense mechanism in the event that tight junctions are breached by acid. It is tempting to speculate that a deficiency of gastric phospholipids may predispose dogs to ulcers. Further, exogenous administration of phospholipids may be useful in preventing gastric ulceration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:20:07