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Titolo:
Development of an automated system for the quick production of N-13-labeled compounds with high specific activity using anhydrous [N-13]NH3
Autore:
Suzuki, K; Yoshida, Y; Shikano, N; Kubodera, A;
Indirizzi:
Natl Inst Radiol Sci, Div Adv Technol Med Imaging, Inage Ku, Chiba 2638555, Natl Inst Radiol Sci Chiba Japan 2638555 aging, Inage Ku, Chiba 2638555, Japan565, & Technol Corp, Subfemtomole Bioregulation Project, Suita, OsakaJapan Sci & Technol Corp Suita Osaka Japan 565 tion Project, Suita, Osaka Sumitomo Accelerator Serv, Shinagawa Ku, Tokyo 141, Japan Sumitomo Accelerator Serv Tokyo Japan 141 Shinagawa Ku, Tokyo 141, Japan Sci Univ Tokyo, Fac Pharmaceut Sci, Shinjuku Ku, Tokyo 162, Japan Sci UnivTokyo Tokyo Japan 162 maceut Sci, Shinjuku Ku, Tokyo 162, Japan
Titolo Testata:
APPLIED RADIATION AND ISOTOPES
fascicolo: 6, volume: 50, anno: 1999,
pagine: 1033 - 1038
SICI:
0969-8043(199906)50:6<1033:DOAASF>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-TARGET PRODUCTION; PROTON IRRADIATION; N-13 AMMONIA; ENZYMATIC-SYNTHESIS; NITROGEN-13-AMMONIA; GLUTAMATE; DISEASE; WATER; FLOW; PET;
Keywords:
nitrogen-13; anhydrous [N-13]NH3; N-13-labeled compounds; specific activity; automation; radiosynthesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Suzuki, K Natl Inst Radiol Sci, Div Adv Technol Med Imaging, Inage Ku, 4-9-1 Anagawa, Natl Inst Radiol Sci 4-9-1 Anagawa Chiba Japan 2638555 Anagawa,
Citazione:
K. Suzuki et al., "Development of an automated system for the quick production of N-13-labeled compounds with high specific activity using anhydrous [N-13]NH3", APPL RAD IS, 50(6), 1999, pp. 1033-1038

Abstract

An automated system was developed to synthesize N-13-labeled compounds with high specific activity using anhydrous [N-13]NH3 as a synthetic precursor. This system enabled (1) production of an aqueous solution of [N-13]NH3, (2) concentration and desiccation of the: [N-13]NH3 solution, (3) reaction of anhydrous [N-13]NH3 with substrate, (4) purification and formulation. By the use of this system, [N-13]p-nitrophenyl carbamate ([N-13]NPC) readyfor i.v, injection could be obtained in 5.1 +/- 0.1 min at the yield of 3.5 +/- 0.4 GBq, specific activity 460 +/- 55 GBq/mu mol, and radiochemical purity > 99% (n = 3) by irradiating a 10 mM ethanol solution with 18 MeV protons at 17 mu A for 25 min. With special precautions, [13N]NPC could be obtained at the extremely high specific activity of 1800 +/- 200 GBq/mu mol. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:34:53