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Titolo:
The effect of surgical stress and endothelin-induced sepsis on the NK-cellactivity, distribution and pulmonary clearance of YAC-1 and melanoma cells
Autore:
Toft, P; Dagnaes-Hansen, F; Tonnesen, E; Basse, PM;
Indirizzi:
AarhuskUniv Hosp, Dept Anaesthesiol & Intens Care, DK-8000 Aarhus C, Denmar Aarhus Univ Hosp Aarhus Denmark C Intens Care, DK-8000 Aarhus C, Denmar Univ Aarhus, Inst Med Microbiol & Immunol, Aarhus, Denmark Univ Aarhus Aarhus Denmark nst Med Microbiol & Immunol, Aarhus, Denmark
Titolo Testata:
APMIS
fascicolo: 4, volume: 107, anno: 1999,
pagine: 359 - 364
SICI:
0903-4641(199904)107:4<359:TEOSSA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; INVIVO; CANCER; IMMUNOMODULATION; CYTOTOXICITY; METASTASIS; ENDOTOXIN; SURGERY;
Keywords:
clearance; endotoxin; natural killer cells; sepsis; surgical stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Toft, P Aarhus Univ Hosp, Dept Anaesthesiol & Intens Care, Norrebrogade 44, DK-8000 Aarhus Univ Hosp Norrebrogade 44 Aarhus Denmark C ade 44, DK-8000
Citazione:
P. Toft et al., "The effect of surgical stress and endothelin-induced sepsis on the NK-cellactivity, distribution and pulmonary clearance of YAC-1 and melanoma cells", APMIS, 107(4), 1999, pp. 359-364

Abstract

Following surgery the activity of natural killer ((NK) cells is decreased in the blood. It is possible that sepsis with release of endotoxin will further decrease the NK-cell activity. The purpose of the present study was toinvestigate the NK-cell cytotoxicity, the clearance in the lungs of YAC-1 and melanoma cells, as well as the distribution of NK-cells in the liver, following abdominal surgery and intraperitoneally (i.p.) administered endotoxin. Ten mice in each group were allocated to abdominal surgery, i.p. endotoxin or anaesthesia alone. Following abdominal surgery, the cytotoxicity ofNK-cells isolated from the spleen was decreased and 4 h after injection the clearance of YAC-1 cells from the lungs was only 79.5+/-6.1% compared to 99.5+/-0.3% in the control group. The number of NK-cells in the liver was also significantly reduced following abdominal surgery. In contrast, i.p. endotoxin increased the activity of NK-cells by 28.5% compared to 11.8% in the control group and 8.1% in the surgery group, lowered the number of melanoma metastases in extrapulmonary organs and significantly increased the number of NK-cells in the liver. Following abdominal surgery, activity of NK-cells, pulmonary clearance and number of NK-cells in the liver were decreased. The number of NK-cells in the liver correlated with the NK-cell activity throughout the study. The increased NK-cell cytotoxicity and the increased number of NK-cells in the liver following i.p. administered endotoxin mightinitially be an appropriate measure against intra-abdominal infection.

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Documento generato il 04/04/20 alle ore 15:25:30