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Titolo:
Clinical evaluation of serum and immunohistochemical expression of SCC andCA19-9 in radiation therapy for cervical cancer
Autore:
Abe, A; Nakano, T; Morita, S; Oka, K;
Indirizzi:
Natl Inst Radiol Sci, Div Radiat Med, Inage Ku, Chiba 263, Japan Natl InstRadiol Sci Chiba Japan 263 iat Med, Inage Ku, Chiba 263, Japan
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 1B, volume: 19, anno: 1999,
pagine: 829 - 836
SICI:
0250-7005(199901/02)19:1B<829:CEOSAI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUAMOUS-CELL CARCINOMA; SIALYL LEWIS-A; CARBOHYDRATE ANTIGEN; VASCULAR ENDOTHELIUM; TUMOR ANTIGEN; ADHESION;
Keywords:
cervical cancer; radiation therapy; SCC; CA19-9; prognosis; immunohistochemical study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Abe, A Natl263,t Radiol Sci, Div Radiat Med, Inage Ku, 9-1 Anagawa 4 Chome, Chiba Natl Inst Radiol Sci 9-1 Anagawa 4 Chome Chiba Japan 263 me, Chiba
Citazione:
A. Abe et al., "Clinical evaluation of serum and immunohistochemical expression of SCC andCA19-9 in radiation therapy for cervical cancer", ANTICANC R, 19(1B), 1999, pp. 829-836

Abstract

The prognostic significance of serum level of SCC and CA19-9 (i.e. sr-SCC and sr-CA19-9) and tumor expression of SCC and CA19-9 (i.e. im-SCC and im-CA19-9) were investigated in patients undergoing radiation therapy for cervical cancer. A total of 103 patients comprising 95 squamous cell carcinomas,3 adenosquamous cell carcinomas and 5 adenocarcinomas, were studied. The tumor expression of SCC and CA19-9 were determined immunohistochemically. The positivity of the patients with abnormal sr-SCC levels for squamous cell carcinoma, adenosquamous cell carcinoma and adenocarcinoma were 87.7 %, 50.0 % and 40.0 %, respectively. The 5-year survival rates of sr-SCC positive and negative patients were 71.1 % and 100 % respectively (P>0.1). The survival rates of im-SCC positive and negative patients were 70.0 % and 80.7 %, respectively (P>0.1). The positivity of patients with im-CA19-9 in squamouscell carcinoma, adenosquamous cell carcinoma, im-CA19-9 adenocarcinoma were 29.1 %, 66.6 %, and 100%, respectively. The 5-year-survival rates of sr-CA19-9 positive patients was 62.5 %, poorer than rite 77.6 % of negative ones (P<0.1). The survival rate of im-CA19-9 expression positive patients was 92.0%, significantly better than the 70.7% in negative patients (P<0.05). Although the sr-SCC level just at the end of radiation therapy was not correlated with local control, re-elevation of the SCC was highly associated with early relapse. These results suggested that follow-up of patients by periodical serum examination for these tumor markers is highly useful for the early detection of tumor relapse.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:38:36