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Titolo:
Preoperative serum E-cadherin assay in patients with ovarian carcinoma
Autore:
Gadducci, A; Ferdeghini, M; Cosio, S; Annicchiarico, C; Ciampi, B; Bianchi, R; Genazzani, AR;
Indirizzi:
Univ Pisa, Dept Procreat Med, Div Obstet & Gynecol, I-56127 Pisa, Italy Univ Pisa Pisa Italy I-56127 , Div Obstet & Gynecol, I-56127 Pisa, Italy Univ Pisa, Dept Oncol, Div Nucl Med, I-56127 Pisa, Italy Univ Pisa Pisa Italy I-56127 pt Oncol, Div Nucl Med, I-56127 Pisa, Italy
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 1B, volume: 19, anno: 1999,
pagine: 769 - 772
SICI:
0250-7005(199901/02)19:1B<769:PSEAIP>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-CELL-ADHESION; MOLECULE E-CADHERIN; INTERCELLULAR-ADHESION; GASTRIC-CANCER; HIGH-GRADE; EXPRESSION; METASTASIS; INVASIVENESS; SURVIVAL; INVASION;
Keywords:
E-cadherin; ovarian carcinoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Gadducci, A Univsa,sa, Dept Procreat Med, Div Obstet & Gynecol, Via Roma 56, I-56127 Pi Univ Pisa Via Roma 56 Pisa Italy I-56127 Roma 56, I-56127 Pi
Citazione:
A. Gadducci et al., "Preoperative serum E-cadherin assay in patients with ovarian carcinoma", ANTICANC R, 19(1B), 1999, pp. 769-772

Abstract

E-cadherin is a 120-kDa transmembrane glycoprotein involved in the calciumdependent adhesion of epithelial cells. Soluble E- cadherin fragment levels have been found to be significantly elevated in patients with different malignancies when compared to healthy controls (Katayama M, ct al. Br: J. Cancer 69, 580-585, 1994). The aim of this paper was to assess the clinical relevance of preoperative serum E-cadherin assay in patients with ovarian carcinoma. E-cadherin was measured with a solid phase enzyme immunoassay based on a sandwich method using two mouse monoclonal anti-human E-cadherin antibodies. Preoperative serum E-cadherin levels were higher in 55 patients with ovarian carcinoma than in 31 patients with benign ovarian disease as controls, even though the difference did not reach the statistical significance (median value, range: 6615 ng/ml, 444-26092 ng/ml versus 5531 ng/ml, 1548-12668 ng/ml, p=0.063). However, the subset of the 36 patients with FIGO stage III-IV ovarian carcinoma had significantly higher antigen levels (median value, range: 7205 ng/ml, 444-26092 ng/ml) when compared to controls (p=0.039). Among patients with advanced ovarian carcinoma, preoperative serum E-cadherin correlated neither with the common clinicopathological prognosticvariables nor with the response to chemotherapy and survival. Our data seem to show that the preoperative serum E-cadherin assay does not offer useful clinical information for the management of patients with ovarian carcinoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 16:24:29