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Titolo:
Clinical study of antalgic drugs
Autore:
Dubray, C;
Indirizzi:
Fac Med, Grp NPPUA, Lab Pharmacol Med, F-63001 Clermont Ferrand, France Fac Med Clermont Ferrand France F-63001 F-63001 Clermont Ferrand, France
Titolo Testata:
THERAPIE
fascicolo: 1, volume: 54, anno: 1999,
pagine: 135 - 145
SICI:
0040-5957(199901/02)54:1<135:CSOAD>2.0.ZU;2-D
Fonte:
ISI
Lingua:
FRE
Soggetto:
EXPERIMENTAL PAIN MODELS; COLD-PRESSOR TEST; HEALTHY-VOLUNTEERS; EVOKED-POTENTIALS; ANALGESIC EFFICACY; NEUROPATHIC PAIN; DOUBLE-BLIND; SECONDARY HYPERALGESIA; NOCICEPTIVE REFLEX; ELECTRICAL STIMULI;
Keywords:
analgesics; experimental pain; methodology; clinical trials;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
97
Recensione:
Indirizzi per estratti:
Indirizzo: Dubray, C FacermontGrp NPPUA, Lab Pharmacol Med, 28 Pl Henri Dunant,BP 38,F-63001 Cl Fac Med 28 Pl Henri Dunant,BP 38 Clermont Ferrand France F-63001
Citazione:
C. Dubray, "Clinical study of antalgic drugs", THERAPIE, 54(1), 1999, pp. 135-145

Abstract

The assessment of the clinical properties of analgesics is not easy. Some of the difficulties are due to the multiplicity of the aetiologies involvedin the pain process, to the complexity of pathophysiological mechanisms modulating the nociception and to the subjectivity of painful sensation. All of these explain the fairly high variability of the criteria available for assessing pain level or pain relief. As a consequence, that variability directly interferes with the pharmacological effect of analgesics to be assessed in clinical trials. Furthermore, the lack of consensus concerning the evaluation criteria does not facilitate the choice of a study design or the comparison of data collected from different clinical trials. Clinicians haveto choose between testing the analgesics in healthy volunteers (experimental pain) or in patients suffering from painful disease (spontaneous pain). These two approaches are often complementary for assessing the pharmacological profile of new analgesic compounds. Whatever the choice, the investigators have to pay attention to the methodological aspects to avoid pitfalls and bias in this difficult field of therapeutic research.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 20:31:42