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Titolo:
Loss of heterozygosity at the ATM locus in colorectal carcinoma
Autore:
Uhrhammer, N; Bay, JO; Pernin, D; Rio, P; Grancho, M; Kwiatkowski, F; Gosse-Brun, S; Daver, A; Bignon, YJ;
Indirizzi:
Ctrerrand,in, Oncol Mol Lab, INSERM, CRI 9502 & EA 2145, F-63011 Clermont F Ctr J Perrin Clermont Ferrand France F-63011 EA 2145, F-63011 Clermont F Ctr P Papin, Serv Radiotherapie, F-49036 Angers, France Ctr P Papin Angers France F-49036 Radiotherapie, F-49036 Angers, France
Titolo Testata:
ONCOLOGY REPORTS
fascicolo: 3, volume: 6, anno: 1999,
pagine: 655 - 658
SICI:
1021-335X(199905/06)6:3<655:LOHATA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATAXIA-TELANGIECTASIA GENE; NIJMEGEN-BREAKAGE-SYNDROME; NONPOLYPOSIS COLON-CANCER; BREAST-CANCER; DNA-DAMAGE; MUTATIONS; REPAIR; IDENTIFICATION; PROTEIN; LINKAGE;
Keywords:
ataxia telangiectasia; colon cancer; loss of heterozygosity; ATM; 11q23; chromosomal instability;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Uhrhammer, N Ctrermontrin, Oncol Mol Lab, INSERM, CRI 9502 & EA 2145, BP 392, F-63011 Cl Ctr J Perrin BP 392 Clermont Ferrand France F-63011 63011 Cl
Citazione:
N. Uhrhammer et al., "Loss of heterozygosity at the ATM locus in colorectal carcinoma", ONCOL REP, 6(3), 1999, pp. 655-658

Abstract

Patients homozygous for mutation of the ATM gene exhibit constitutional genetic instability and have a high risk of cancer. A-T heterozygotes also have an increased tendency to develop adenocarcinomas. Colorectal cancer (CRC) is the second most common cancer in western populations, and tumors of the right colon are typically highly genetically unstable. The DNA mismatch repair genes mutated in most familial and some sporadic CRCs account for oneroute by which cells acquire additional oncogenic mutations during the progression of malignancy. Mismatch repair defects, however, do not seem to account for the majority of CRCs. Because of its role in maintaining genomic stability, and the high risk of cancer to homozygotes, ATM is a candidate gene for inactivation in the evolution of chromosomal instability in tumor cells. We have examined 114 CRC patients for loss of heterozygosity (LOH) using six microsatellite markers tightly linked to the ATM locus. Our data suggest that LOH of this region is not associated with cancer of the proximalcolon. In the distal colon, LOH was found in 23-31% of cases, which is moderately elevated above the non-specific LOH reported in tumors of this tissue. No correlations were found with regard to clinicopathological variablesaside from tumor location.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:49:54