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Titolo:
DIETARY NUCLEOTIDES - EFFECTS ON CELL-PROLIFERATION FOLLOWING PARTIAL-HEPATECTOMY IN RATS FED NIH-31, AIN-76A, OR FOLATE METHYL-DEFICIENT DIETS/
Autore:
JACKSON CD; WEIS C; MILLER BJ; JAMES SJ;
Indirizzi:
NATL CTR TOXICOL RES,DIV NUTR TOXICOL JEFFERSON AR 72079
Titolo Testata:
The Journal of nutrition
, volume: 127, anno: 1997, supplemento:, 5
pagine: 834 - 837
SICI:
0022-3166(1997)127:<834:DN-EOC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PANCREATIC CARCINOGENESIS; OROTIC-ACID; DNA; INHIBITION; MISINCORPORATION; PERTURBATIONS; LYMPHOCYTES; TOXICITY; LIVER; POOLS;
Keywords:
DIETARY NUCLEOTIDES; CELL PROLIFERATION; PURIFIED DIETS; F344 RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
C.D. Jackson et al., "DIETARY NUCLEOTIDES - EFFECTS ON CELL-PROLIFERATION FOLLOWING PARTIAL-HEPATECTOMY IN RATS FED NIH-31, AIN-76A, OR FOLATE METHYL-DEFICIENT DIETS/", The Journal of nutrition, 127, 1997, pp. 834-837

Abstract

The requirement of a number of tissues for dietary nucleotides could explain some of the differences observed in animals fed natural ingredient diets vs. those fed purified diets lacking a source of dietary nucleotides. Lack of dietary nucleotides is exacerbated in animals fed folate- or methyl-deficient semipurified diets, in which both salvage and folate-dependent de novo synthetic pathways are diminished. We examined hepatocyte proliferation following partial hepatectomy in weanling male Fischer-344 rats fed natural ingredient NIH-31 diet, nucleotide-free purified AIN-76A diet or a basal diet similar to AIN-76A but deficient in the methyl donors folate, choline and methionine. Additionalgroups were fed AIN-76A or folate/methyl-deficient diets supplementedwith 0.25% yeast RNA. Compared with NIH-31,AIN-76A increased dUMP/dTTP ratios, reduced the mitotic index (MI) and increased the ratio of proliferating cell index (PCI) to mitotic cells, an indication that hepatocytes were delayed in S-phase. Addition of yeast RNA to AIN-76A reversed (by approximately 50%) the effects of AIN-76A on dUMP/dTTP and cell proliferation. A folate/methyl-deficient diet also produced an increased dUMP/dTTP ratio and markedly reduced the MI, increasing the PCI/MI, which suggested even further delay of cells in S-phase. Addition of yeast RNA to the folate/methyl-deficient diet was effective in significantly reversing the effects of folate/methyl deficiency.

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Documento generato il 14/07/20 alle ore 10:15:47