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Titolo:
PET imaging of the dopamine transporter in progressive supranuclear palsy and Parkinson's disease
Autore:
Ilgin, N; Zubieta, J; Reich, SG; Dannals, RF; Ravert, HT; Frost, JJ;
Indirizzi:
Johnsed,pkins Univ, Sch Med, Dept Radiol,Johns Hopkins Med Inst, Div Nucl M Johns Hopkins Univ Baltimore MD USA 21287 ns Hopkins Med Inst, Div Nucl M Johns Hopkins med Inst, Dept Neurol, Baltimore, MD USA Johns Hopkins med Inst Baltimore MD USA , Dept Neurol, Baltimore, MD USA Johns Hopkins med Inst, Dept Neurosci, Baltimore, MD USA Johns Hopkins medInst Baltimore MD USA Dept Neurosci, Baltimore, MD USA
Titolo Testata:
NEUROLOGY
fascicolo: 6, volume: 52, anno: 1999,
pagine: 1221 - 1226
SICI:
0028-3878(19990412)52:6<1221:PIOTDT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; MULTIPLE SYSTEM ATROPHY; RICHARDSON-OLSZEWSKI SYNDROME; STRIATONIGRAL DEGENERATION; CLINICAL-DIAGNOSIS; WIN-35,428; METABOLISM; ACCURACY; BINDING; PATTERN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Frost, JJ Johnsed,pkins Univ, Sch Med, Dept Radiol,Johns Hopkins Med Inst,Div Nucl M Johns Hopkins Univ Nelson Bldg B1-130,600 N Wolfe St Baltimore MD USA 21287
Citazione:
N. Ilgin et al., "PET imaging of the dopamine transporter in progressive supranuclear palsy and Parkinson's disease", NEUROLOGY, 52(6), 1999, pp. 1221-1226

Abstract

Objective: To differentiate the patterns of dopamine transporter loss between idiopathic PD and progressive supranuclear palsy (PSP). Methods: We used the radiotracer [C-11]-WIN 35,428 and PET. Regional striatal dopamine transporter binding was measured in the caudate, anterior putamen, and posterior putamen of six patients with L-dopa-responsive stage 2 PD, six patients with PSP, and six age-comparable healthy controls. Results: in patients with idiopathic PD, the most marked abnormality was observed in the posterior putamen (77% reduction), whereas transporter density in the anterior putamen (60% reduction) and the caudate (44% reduction) was less affected. Unlikethe patients with PD, the PSP group showed a relatively uniform degree of involvement in the caudate (40% reduction), anterior putamen (47% reduction), and posterior putamen (51% reduction). When posterior putamen/caudate ratios were calculated, these values were significantly lower in patients with PD than they were in patients with PSP (p = 0.0008) and the control group(p < 0.0001). Conclusions: Patients with PD have a more pronounced loss ofdopamine transporters in the posterior putamen due to a subdivisional involvement of nigrostriatal dopaminergic projections in idiopathic PD. This technique is useful in the determination of neurochemical changes underlying PD and PSP, thus differentiating between them.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:30:02