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Titolo:
Outward currents influencing bursting dynamics in guinea pig trigeminal motoneurons
Autore:
del Negro, CA; Hsiao, CF; Chandler, SH;
Indirizzi:
Univ Calif Los Angeles, Dept Physiol Sci, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
JOURNAL OF NEUROPHYSIOLOGY
fascicolo: 4, volume: 81, anno: 1999,
pagine: 1478 - 1485
SICI:
0022-3077(199904)81:4<1478:OCIBDI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; ELECTROGENIC SODIUM-PUMP; RAT SPINAL-CORD; DOPAMINE NEURONS; IN-VITRO; ELECTROPHYSIOLOGICAL PROPERTIES; HYPOGLOSSAL MOTONEURONS; ELECTRICAL-PROPERTIES; OSCILLATORY ACTIVITY; MEMBRANE-PROPERTIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Chandler, SH UnivCAalif Los Angeles, Dept Physiol Sci, 2851 Slichter Hall,Los Angeles, Univ Calif Los Angeles 2851 Slichter Hall Los Angeles CA USA 90095
Citazione:
C.A. del Negro et al., "Outward currents influencing bursting dynamics in guinea pig trigeminal motoneurons", J NEUROPHYS, 81(4), 1999, pp. 1478-1485

Abstract

To initiate and maintain bursts (and plateau potentials) in the presence of serotonin, guinea pig trigeminal motoneurans utilize L-type Ca2+ and persistent Na+ inward currents. However, the intrinsic currents that contributeto burst termination and determine the duration of the interburst intervalare unknown. Therefore we investigated the roles of outward currents. whose slow activation is coupled to cytosolic cation (Ca2+ and Na+) accumulation. First we examined a Ca2+-dependent K+ current (IK-Ca) with apamin and Ba2+-substituted, low-Ca2+ solution. Blockade of IK-Ca lengthened burst duration and cycle time but did not abolish bursting. Next we studied the Na+/K+-ATPase pump current (I-p) with cardiac glycosides. Ln the presence nf apamin or low-Ca2+/Ba2+ solution, blocking I-p (with ouabain or strophanthidin)decreased both burst duration and cycle time and ultimately transformed bursting into tonic spiking. We conclude that IK-Ca and I-p contribute to burst termination in trigeminal motoneurons. These currents influence temporalbursting properties such as burst duration and cycle time and may help determine the phasic activity of motoneurons during rhythmic oral-motor behaviors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:55:56