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Titolo:
Reduced corticotropin-releasing factor and enhanced vasopressin gene expression in brains of mice with autoimmunity-induced behavioral dysfunction
Autore:
Sakic, B; Laflamme, N; Crnic, LS; Szechtman, H; Denburg, JA; Rivest, S;
Indirizzi:
McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON L8N 3Z5, Canada McMaster Univ Hamilton ON Canada L8N 3Z5 ci, Hamilton, ON L8N 3Z5, Canada McMaster Univ, Dept Med, Hamilton, ON, Canada McMaster Univ Hamilton ON Canada er Univ, Dept Med, Hamilton, ON, Canada CHUL, Res Ctr, Mol Endocrinol Lab, Quebec City, PQ, Canada CHUL Quebec City PQ Canada , Mol Endocrinol Lab, Quebec City, PQ, Canada Univ Colorado, Sch Med, Dept Pediat, Denver, CO USA Univ Colorado Denver CO USA lorado, Sch Med, Dept Pediat, Denver, CO USA Univ Colorado, Sch Med, Dept Psychiat, Denver, CO 80262 USA Univ ColoradoDenver CO USA 80262 ed, Dept Psychiat, Denver, CO 80262 USA
Titolo Testata:
JOURNAL OF NEUROIMMUNOLOGY
fascicolo: 1, volume: 96, anno: 1999,
pagine: 80 - 91
SICI:
0165-5728(19990401)96:1<80:RCFAEV>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL AXIS; MRL-LPR MICE; SYSTEMIC LUPUS-ERYTHEMATOSUS; PROOPIOMELANOCORTIN MESSENGER-RNA; CA3 PYRAMIDAL NEURONS; IMMUNOENDOCRINE COMMUNICATION; PARAVENTRICULAR NUCLEUS; INFLAMMATORY DISEASE; APICAL DENDRITES; STRESS RESPONSE;
Keywords:
corticotropin-releasing factor; vasopressin; limbic system; behavioral dysfunction; autoimmunity; inflammation; MRL-lpr mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Sakic, B McMastermilton,Dept Psychiat & Behav Neurosci, HSC 4N77A,1200 Main St W, Ha McMaster Univ HSC 4N77A,1200 Main St W Hamilton ON Canada L8N 3Z5
Citazione:
B. Sakic et al., "Reduced corticotropin-releasing factor and enhanced vasopressin gene expression in brains of mice with autoimmunity-induced behavioral dysfunction", J NEUROIMM, 96(1), 1999, pp. 80-91

Abstract

The spontaneous development of autoimmune disease in MRL-1pr mice induces behavioral and endocrine changes that resemble effects of chronic stressors. To further examine the correspondence between autoimmune disease and chronic stress, we asked whether the brains of autoimmune mice show a shift in the corticotropin-releasing factor (CRF) to vasopressin (AVP) ratio. Using in situ hybridization histochemistry with S-35-labelled mouse riboprobes, the levels of mRNA transcripts encoding CRF and AVP were compared between autoimmune MRL-1pr and control MRL +/+ brains. CRF transcript levels were lower in the hypothalamic paraventricular nucleus and in the central nucleus of the amygdala in MRL-1pr mice. AVP transcript levels were higher in the paraventricular and the supraoptic nuclei in MRL-1pr mice compared to controls. CRF mRNA levels were inversely related to performance in stress-sensitive tasks and to measures of autoimmunity. As found previously for behavioralperformance, immunosuppressive treatment with cyclophosphamide abolished the group difference in neuropeptide gene expression. These results indicatethat an autoimmune disease process is necessary for the shift in the brainCRF:AVP ratio. Furthermore, they support the parallel between chronic stress and chronic autoimmunity/inflammation, and suggest common central mechanisms relevant to endocrine function and behavior. (C) 1999 Elsevier ScienceB.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 12:47:40