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Titolo:
Elevated levels of circulating immunostimulatory 90K in Henoch-Schoenlein purpura
Autore:
Pelliccia, P; Natoli, C; Petitti, MT; Verrotti, A; Chiarelli, F; Iacobelli, S;
Indirizzi:
Univ Chieti, Dept Med, Div Pediat & Neonatol, Chieti, Italy Univ Chieti Chieti Italy Dept Med, Div Pediat & Neonatol, Chieti, Italy
Titolo Testata:
JOURNAL OF CLINICAL IMMUNOLOGY
fascicolo: 2, volume: 19, anno: 1999,
pagine: 143 - 147
SICI:
0271-9142(199903)19:2<143:ELOCI9>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-ASSOCIATED ANTIGEN; INTERCELLULAR-ADHESION MOLECULE-1; CYSTEINE-RICH DOMAIN; BREAST-CANCER; BINDING-PROTEIN; MONOCLONAL-ANTIBODY; CELL-LINE; EXPRESSION; TISSUE; MAC-2;
Keywords:
Schoenlein-Henoch purpura; sICAM; 90K/Mac-2 BP protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Pelliccia, P Osped66100clin Colle DellAra, Div Pediat, Div Pediat, Via deiVestini 5, I- Osped Policlin Colle DellAra Via dei Vestini 5 Chieti ItalyI-66100
Citazione:
P. Pelliccia et al., "Elevated levels of circulating immunostimulatory 90K in Henoch-Schoenlein purpura", J CLIN IMM, 19(2), 1999, pp. 143-147

Abstract

In order to clarify the immunologic reaction present in Henoch-Schoenlein purpura (HSP), 20 children (11 boys and 9 girls; median age, 5.8 +/- 2.8 years) with HSP and 20 sex- and age-matched healthy children were studied. The 90K/Mac-2 BP serum concentrations were significantly higher in the patients than in the healthy controls (12.5 +/- 75 vs 4.5 +/- 2.7 mu g/ml, respectively; P < 0.0001). 90K/Mac-2 BP values higher than the cutoff value were observed in 13 of 20 (65%) patient. The soluble intercellular adhesion molecule 1 concentrations were significantly higher in HSP patients than controls (P < 0.0001). with mean values of 1631 +/- 703 and 85 +/- 16 ng/ml, respectively. The 90K/Mac-2 BP serum levels were significantly correlated with soluble intercellular adhesion molecule 1 (r = 0.90, P < 0.0001). Although the underlying causes of these immunological abnormalities are unclear, these observations suggest that the 90K/Mac-2 BP protein may play a role in the immunological reactions involved in the development of HSP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 11:23:00