Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Measurement of striatal D-2 dopamine receptor density and affinity with [C-11]-raclopride in vivo: A test-retest analysis
Autore:
Hietala, J; Nagren, K; Lehikoinen, P; Ruotsalainen, U; Syvalahti, E;
Indirizzi:
Turku Univ, Cent Hosp, Dept Psychiat 721, Turku 20520, Finland Turku UnivTurku Finland 20520 , Dept Psychiat 721, Turku 20520, Finland Univ Turku, Turku PET Ctr, Turku, Finland Univ Turku Turku FinlandUniv Turku, Turku PET Ctr, Turku, Finland Univ Turku, Dept Pharmacol & Clin Pharmacol, Turku, Finland Univ Turku Turku Finland ept Pharmacol & Clin Pharmacol, Turku, Finland
Titolo Testata:
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
fascicolo: 2, volume: 19, anno: 1999,
pagine: 210 - 217
SICI:
0271-678X(199902)19:2<210:MOSDDR>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; NAIVE SCHIZOPHRENIC-PATIENTS; C-11 RACLOPRIDE BINDING; HUMAN-BRAIN; N-METHYLSPIPERONE; PET ANALYSIS; EQUILIBRIUM; RELIABILITY; AGE;
Keywords:
dopamine; D-2 dopamine receptor; positron emission tomography; raclopride; schizophrenia; variability; reproducibility;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Hietala, J Turku Univ, Cent Hosp, Dept Psychiat 721, Turku 20520, Finland Turku Univ Turku Finland 20520 hiat 721, Turku 20520, Finland
Citazione:
J. Hietala et al., "Measurement of striatal D-2 dopamine receptor density and affinity with [C-11]-raclopride in vivo: A test-retest analysis", J CEREBR B, 19(2), 1999, pp. 210-217

Abstract

Subacute acid long-term stability of measurements of D-2 dopamine receptordensity (Bmax), affinity (Kd) was studied with positron emission tomography in eight healthy male volunteers. [C-11]-Raclopride and the transient equilibrium method were used to measure D-2 receptor characteristics. The interval between measurements (scan pairs) was 3 to 7 weeks (subacute) for foursubjects and 6 to 11 months (long-term) for four subjects. A test-retest analysis of quantitative measurements of D-2 receptor Bmax and Kd was compared with that done on binding potential (BP, Bmax/Kd) measures. In addition,the effect of error in defining the transient equilibrium time (tmax) in the parameter estimation procedure was explored with simulations. The subacute test-retest indicates good reproducibility of D-2 receptor density, affinity, and BP ratio measurements with intraclass correlation coefficients of0.90, 0.96, and 0.86, respectively. The variability of the measurements after 6 to 11 months was slightly higher than that seen in a subacute testingfor Kd and more clearly so for binding potential and Bmax. The absolute variability in Bmax (14.5%) measurements was consistently higher than that ofKd (8.4%) or BP (7.9%) both in subacute and long-term measurements. Simulations indicated that the Bmax and Kd estimation procedure is more sensitiveto error in the tmax than that for the BP. The results indicate a good overall stability of the equilibrium method with [C-11]raclopride for measuring dopamine D-2 receptor binding characteristics in the striatum. The BP approach is more stable than Kd and especially Bmax measurements. Error in defining the tmax in particular in the low specific radioactivity scan may be one source of greater variability in Bmax versus BP. However, a higher intraindividual variability in measurements of the D-2 receptor Bmax also may include a component of continuous regulation of this parameter over time. These methodologic aspects should be considered in the design and interpretation of longitudinal studies on D-2 dopamine receptor characteristics with [C-11]-raclopride.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 15:21:36