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Titolo:
Evaluation of dopaminergic presynaptic integrity: 6-[F-18]fluoro-L-dopa versus 6-[F-18]fluoro-L-m-tyrosine
Autore:
Doudet, DJ; Chan, GLY; Jivan, S; DeJesus, OT; McGeer, EG; English, C; Ruth, TJ; Holden, JE;
Indirizzi:
Univ British Columbia, Div Neurol, Vancouver, BC V6T 2B5, Canada Univ British Columbia Vancouver BC Canada V6T 2B5 ver, BC V6T 2B5, Canada UnivaBritish Columbia, Kinsmen Lab Neurol Res, Vancouver, BC V6T 2B5, Canad Univ British Columbia Vancouver BC Canada V6T 2B5 uver, BC V6T 2B5, Canad Univ British Columbia, TRIUMF, Vancouver, BC V6T 2B5, Canada Univ British Columbia Vancouver BC Canada V6T 2B5 ver, BC V6T 2B5, Canada Univ Wisconsin, Dept Med Phys, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 Dept Med Phys, Madison, WI 53706 USA
Titolo Testata:
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
fascicolo: 3, volume: 19, anno: 1999,
pagine: 278 - 287
SICI:
0271-678X(199903)19:3<278:EODPI6>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CATECHOL-O-METHYLTRANSFERASE; MPTP-INDUCED PARKINSONISM; HUMAN-BRAIN; REGIOSELECTIVE RADIOFLUORODESTANNYLATION; COMT INHIBITION; F-18 F2; PET; METABOLISM; KINETICS;
Keywords:
6-[F-18]L-dopa; 6-[F-18]L-m-tyrosine; dopamine neurons; positron emission tomography; dopamine turnover;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Doudet, DJ Univ British Columbia, Div Neurol, Room M36,Purdy Pavil,2221 Wesbrook Mall, Univ British Columbia Room M36,Purdy Pavil,2221 Wesbrook Mall Vancouver BC Canada V6T 2B5
Citazione:
D.J. Doudet et al., "Evaluation of dopaminergic presynaptic integrity: 6-[F-18]fluoro-L-dopa versus 6-[F-18]fluoro-L-m-tyrosine", J CEREBR B, 19(3), 1999, pp. 278-287

Abstract

The effectiveness of 6-[F-18]fluoro-L-m-tyrosine (6FMT) to evaluate dopamine: presynaptic integrity was compared to that of 6-[F-18]fluoro-L-dopa (6FDOPA) in vivo by positron emission tomography (PET). Six normal and six 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) -lesioned monkeys received6FDOPA and 6FMT PET scans on separate occasions with identical scanning protocols. Four measures, the rate of uptake of tracer into striatum using either the arterial input function (K-i) or the activity in the occipital cortex as the input function (K-c), the rate of loss of striatal radioactivity(k(loss)), and an index of ''effective turnover'' of dopamine (k(loss)/K-i), were obtained for both tracers during extended PET studies. 6-[F-18]Fluoro-L-m-tyrosine was as effective as 6FDOPA in separating normals from MPTP-lesioned subjects on the basis of the uptake rate constants K-i and K-c. However, in contrast to 6FDOPA, it was not possible to differentiate the normal from the lesioned animal using k(loss) or k(loss)/K-i for 6FMT. Thus, FMT appears to be a reasonable, highly specific tracer for studying the activity of aromatic dopa decarboxylase enzyme as an index of presynaptic integrity. However, if one is interested in investigating further the metabolic pathway and obtaining an irt vivo estimate of the effective turnover of dopamine (after pharmacologic manipulation, for example), 6FDOPA remains the tracer of choice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 01:51:07