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Titolo:
Analysis of optical signals evoked by peripheral nerve stimulation in rat somatosensory cortex: Dynamic changes in hemoglobin concentration and oxygenation
Autore:
Nemoto, M; Nomura, Y; Sato, C; Tamura, M; Houkin, K; Koyanagi, I; Abe, H;
Indirizzi:
HokkaidoJapan, Res Inst Elect Sci, Div Biophys, Sapporo, Hokkaido 0600812,Hokkaido Univ Sapporo Hokkaido Japan 0600812 , Sapporo, Hokkaido 0600812, Hokkaido Univ, Sch Med, Dept Neurosurg, Sapporo, Hokkaido 060, Japan Hokkaido Univ Sapporo Hokkaido Japan 060 rg, Sapporo, Hokkaido 060, Japan
Titolo Testata:
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
fascicolo: 3, volume: 19, anno: 1999,
pagine: 246 - 259
SICI:
0271-678X(199903)19:3<246:AOOSEB>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; HUMAN VISUAL-CORTEX; INTRINSIC SIGNALS; NEURONAL-ACTIVITY; FUNCTIONAL ARCHITECTURE; SENSORY STIMULATION; ELECTRICAL-ACTIVITY; HIPPOCAMPAL SLICES; LIGHT-SCATTERING; STIMULUS RATE;
Keywords:
optical imaging; microspectrophotometry; laser-Doppler flowmetry; optical intrinsic signals; hemoglobin concentration and oxygenation; neurovascular coupling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Nemoto, M HokkaidoJapan, Res Inst Elect Sci, Div Biophys, Sapporo, Hokkaido 0600812, Hokkaido Univ Sapporo Hokkaido Japan 0600812 Hokkaido 0600812,
Citazione:
M. Nemoto et al., "Analysis of optical signals evoked by peripheral nerve stimulation in rat somatosensory cortex: Dynamic changes in hemoglobin concentration and oxygenation", J CEREBR B, 19(3), 1999, pp. 246-259

Abstract

The origins of reflected light changes associated with neuronal activity (optical signals) were investigated in rat somatosensory cortex with opticalimaging, microspectrophotometry, and laser-Doppler flowmetry, and dynamic changes in local hemoglobin concentration and oxygenation were: focused on. Functional activation was carried out by 2-second, 5-Hz electrical stimulation of the hind limb under chloralose anesthesia. These measurements were performed at the contralateral parietal cortex through a thinned skull. Regional cortical blood flow (rCBF) started to rise 1.5 seconds after the stimulus onset, peaked at 3.5 seconds (26.7% +/- 9.7% increase over baseline), and returned to near baseline by 10 seconds. Optical signal responses at 577, 586, and 805 nm showed a monophasic increase in absorbance coincident with the increase in rCBF; however, the signal responses at 605 and 760 nm were biphasic (an early increase and late decrease in absorbance) and micro-anatomically heterogeneous. The spectral changes of absorbance indicated that the concentrations of both total hemoglobin and oxyhemoglobin increased together with rCBF; deoxyhemoglobin, increased slightly but distinctly (P = 0.016 at 1.0 seconds, P = 0.00038 at 1.5 seconds) just before rCBF increases, then decreased. The authors conclude that activity-related optical signals are greatly associated with a moment-to-moment adjustment of rCBF and metabolism to neuronal activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 06:54:27