Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Comparison between nasal provocation tests and skin tests in patients treated with loratadine and cetirizine
Autore:
Persi, L; Demoly, P; Harris, AG; Tisserand, B; Michel, FB; Bousquet, J;
Indirizzi:
Hop Arnaud de Villeneuve, F-34295 Montpellier 5, France Hop Arnaud de Villeneuve Montpellier France 5 4295 Montpellier 5, France Integrated Therapeut Grp Inc, Kenilworth, NJ USA Integrated Therapeut Grp Inc Kenilworth NJ USA p Inc, Kenilworth, NJ USA ITEM, Verum, France ITEM Verum FranceITEM, Verum, France
Titolo Testata:
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
fascicolo: 4, volume: 103, anno: 1999,
pagine: 591 - 594
SICI:
0091-6749(199904)103:4<591:CBNPTA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLACEBO-CONTROLLED IMMUNOTHERAPY; GRASS-POLLEN ALLERGOIDS; DOUBLE-BLIND; PHARMACOLOGICAL MODULATION; RUSH IMMUNOTHERAPY; HISTAMINE; TERFENADINE; EFFICACY; ASTEMIZOLE; SUPPRESSION;
Keywords:
orchard grass; nasal provocation test; rhinitis; loratadine; cetirizine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Bousquet, J Hop Arnaud de Villeneuve, F-34295 Montpellier 5, France Hop Arnaud de Villeneuve Montpellier France 5 lier 5, France
Citazione:
L. Persi et al., "Comparison between nasal provocation tests and skin tests in patients treated with loratadine and cetirizine", J ALLERG CL, 103(4), 1999, pp. 591-594

Abstract

Background: The effect of H1-blockers may differ depending on the target organ. Objective: A double-blind, placebo-controlled study was carried out to compare the effect of a 7-day treatment with loratadine (10 mg daily) or cetirizine (10 mg daily) on nasal challenge with grass pollen grains and skin tests with allergen or histamine. Methods: Twenty-four patients were enrolled, but the analysis was carried out on 23, Nasal challenge was carried out by using 5-fold increasing numbers of pollen grains. Skin prick tests were done with serial concentrations of allergens and 1 concentration of histamine. Patients were tested in a cross-over design, with each treatment being administered for the previous 7 days and with a 2-week washout period. Results: By comparison with placebo, loratadine and cetirizine increased significantly the threshold number of pollen grains required to induce a positive nasal challenge (P < .001). There was no difference between loratadine and cetirizine, Skin test responses to allergen were significantly reduced by loratadine and cetirizine by comparison with placebo. Skin test responses to histamine were significantly decreased by the 2 H1-blockers, but they were more profoundly decreased by cetirizine than by loratadine. Conclusions: Both Hi-blockers reduced similarly allergen-induced skin testand nasal challenge responses. Cetirizine was more effective on histamine skin test responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/18 alle ore 08:41:56