Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Leptin values in placental cord blood of human newborns with normal intrauterine growth after 30-42 weeks of gestation
Autore:
Gomez, L; Carrascosa, A; Yeste, D; Potau, N; Rique, S; Ruiz-Cuevas, P; Almar, J;
Indirizzi:
Autonomous-08035Barcelona, Hosp Maternoinfantil Vall Hebron, Dept Pediat, E Autonomous Univ Barcelona Barcelona Spain E-08035 Hebron, Dept Pediat, E Autonomoust,niv Barcelona, Hosp Maternoinfantil Vall Hebron, Adolescent Uni Autonomous Univ Barcelona Barcelona Spain E-08035 Hebron, Adolescent Uni Autonomous,Univ Barcelona, Hosp Maternoinfantil Vall Hebron, Endocrine Unit Autonomous Univ Barcelona Barcelona Spain E-08035 Hebron, Endocrine Unit Autonomousit,iv Barcelona, Hosp Maternoinfantil Vall Hebron, Hormone Lab Un Autonomous Univ Barcelona Barcelona Spain E-08035 Hebron, Hormone Lab Un
Titolo Testata:
HORMONE RESEARCH
fascicolo: 1, volume: 51, anno: 1999,
pagine: 10 - 14
SICI:
0301-0163(199901)51:1<10:LVIPCB>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM LEPTIN; AMNIOTIC-FLUID; MATERNAL SERUM; BIRTH-WEIGHT; GENDER; PLASMA; ARTERIAL; GENE;
Keywords:
leptin; human placental cord blood; human newborn;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Carrascosa, A AutonomousasseigBarcelona, Hosp Maternoinfantil Vall Hebron,Dept Pediat, P Autonomous Univ Barcelona Passeig Vall Hebron 119-129 Barcelona Spain E-08035
Citazione:
L. Gomez et al., "Leptin values in placental cord blood of human newborns with normal intrauterine growth after 30-42 weeks of gestation", HORMONE RES, 51(1), 1999, pp. 10-14

Abstract

Objective: To evaluate leptin values in placental cord blood of newborns with normal intrauterine growth after 30-42 weeks of gestation. Design: Leptin, a protein encoded by the ob gene, plays an important role in the regulation of feeding behaviour and energy balance in rodents, primates and humans. The presence of leptin in human amniotic fluid and cord blood has recently been reported in human gestations at term and the possible role of leptin in human fetal growth suggested. However, little is known of leptin synthesis during human foetal development. Thus, the aim of our work was to measure leptin (RIA, Linco Research, Inc.) in placental cord blood of human newborns at different fetal ages. Patients: One hundred and twenty-six healthynewborns with normal intra uteri ne growth were studied. Twenty-nine were preterm (15 males and 14 females; gestational age: 30-36 weeks) and 99 wereat term (49 males and 48 females; gestational age: 37-42 weeks). Results: Leptin values increase progressively throughout gestation from 1.30 +/- 0.53 ng/ml at 30 weeks of gestation to 7.98 +/- 4.96 ng/ mi (mean +/- SD) at term, and correlate positively with birth weight (r = 0.56, p < 0.005, n = 126), length (r = 0.37, p < 0.005, n = 126), BMI (r = 0.57, p < 0.005, n = 126), head circumference (r = 0.37, p < 0.005, n = 126), gestational age (r = 0.48, p < 0.005, n = 126) and placental weight (r = 0.38, p < 0.003, n = 59). Leptin values are statistically significantly lower (p < 0.005) preterm (median: 2.05 ng/ml; range: 0.7-8.3 ng/ml) than at term (median: 7.0 ng/ml; range: 1.1-28.1 ng/ml). Leptin values are also significantly (p < 0.005)higher in females (median: 7.2 ng/ml; range: 0.9-23.6 ng/ml, n = 62) than in males (median: 4.8 ng/ml; range: 0.7-28.1 ng/ml, n = 64), although thereare no differences in weight (2,864 +/- 536 g in females vs. 2,937 +/- 744g in males). Multiple regression analysis shows weight to be a positive sex-independent predictor of serum leptin values (p < 0.0005). Sex also proves to be a predictor of leptin, independently of weight and is higher in females than in males (p < 0.003). Conclusion: Leptin is present in placental human cord blood after 30-42 weeks of gestation. Newborn weight and sex areindependent predictors of leptin values.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 17:56:43