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Titolo:
The role of the GH/IGF-I axis for cardiac function and structure
Autore:
Isgaard, J; Tivesten, A; Friberg, P; Bengtsson, BA;
Indirizzi:
Sahlgrens Univ Hosp, Res Ctr Endocrinol & Metab, S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41345 S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp, Dept Clin Physiol, S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41345 S-41345 Gothenburg, Sweden
Titolo Testata:
HORMONE AND METABOLIC RESEARCH
fascicolo: 2-3, volume: 31, anno: 1999,
pagine: 50 - 54
SICI:
0018-5043(199902/03)31:2-3<50:TROTGA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-I; EXPERIMENTAL HEART-FAILURE; HORMONE-RELEASING PEPTIDE; GENE-EXPRESSION; VENTRICULAR HYPERTROPHY; DILATED CARDIOMYOPATHY; MYOCARDIAL-INFARCTION; MESSENGER-RNA; RENAL-HYPERTENSION; VITRO EVALUATION;
Keywords:
growth hormone; insulin-like growth factor; cardiac; heart;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Isgaard, J Sahlgrensothenburg,, Res Ctr Endocrinol & Metab, Grona Straket 8, S-41345 G Sahlgrens Univ Hosp Grona Straket 8 Gothenburg Sweden S-41345
Citazione:
J. Isgaard et al., "The role of the GH/IGF-I axis for cardiac function and structure", HORMONE MET, 31(2-3), 1999, pp. 50-54

Abstract

There is ample evidence to support a role for the GH/ICF-I axis in regulation of cardiac growth, structure and function. GH may act directly on the heart or through circulating IGF-I (Fig, 1). Moreover, GH has been found to regulate local production of IGF-I in the heart. Both the GH-R and IGF-I-R are expressed in cardiac tissue. Hence, the IGF-I-R receptor can theoretically be activated through locally produced IGF-I acting via autocrine/paracrine mechanisms, or via circulating IGF-I exerting its effects as an endocrine agent. During conditions of pressure and volume overload, an increased systolic wall stress triggers an induction of gene expression of IGF-I GH-R and possibly IGF-I-R implying a potential role for the GH/IGF-I axis in thedevelopment of adaptive hypertrophy of the heart and vessels. Cardiovascular effects of GH in clinical studies include beneficial effects on contractility, exercise performance and TPR, and experimental studies suggest an increased Ca2+ responsiveness as one possible underlying cause, although effects of GH and IGF-I on apoptosis may possibly also play a role. The GH secretagogue hexarelin improves cardiac function after experimental myocardial infarction either through an increased GH secretion or possibly through a cardiac GHS receptor, although this needs further investigation. Moreover, it is clear that further basic and clinical studies are required to gain insight into the GH and IGF-I mechanisms of action and to monitor long-term effects when GH is administered as substitution therapy or as an agent in thetreatment of congestive heart failure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 00:49:04