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Titolo:
Substituted benzimidazoles. Part 2. Synthesis and properties of 2-aryl-hydroxy-5-(2-thenoyl)benzimidazole 3-oxides
Autore:
Kamal, MR; El-Abadelah, MM; Mohammad, AA;
Indirizzi:
Univ Jordan, Dept Chem, Amman, Jordan Univ Jordan Amman JordanUniv Jordan, Dept Chem, Amman, Jordan Univ Mainz, Inst Organ Chem, D-55099 Mainz, Germany Univ Mainz Mainz Germany D-55099 Inst Organ Chem, D-55099 Mainz, Germany
Titolo Testata:
HETEROCYCLES
fascicolo: 2, volume: 50, anno: 1999,
pagine: 819 - 832
SICI:
0385-5414(19990401)50:2<819:SBP2SA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
BENZOFURAZAN OXIDE; N-OXIDES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Kamal, MR Univ Jordan, Dept Chem, Amman, Jordan Univ Jordan Amman Jordan niv Jordan, Dept Chem, Amman, Jordan
Citazione:
M.R. Kamal et al., "Substituted benzimidazoles. Part 2. Synthesis and properties of 2-aryl-hydroxy-5-(2-thenoyl)benzimidazole 3-oxides", HETEROCYCLE, 50(2), 1999, pp. 819-832

Abstract

A selected set of 2-aryl- and 2-hetaryl-1-hydroxy-5-(2-thenoyl)benzimidazole 3-oxides (10a-m) was prepared for bioassay via condensation of the corresponding aldehydes with 4-(2-thenoyl)-1,2-benzoquinone dioxime (8) as catalyzed by perchloric acid. The dioxime (8) was obtained by facile reduction of 5-(2-thenoyl)benzofuroxan (7a) with 1,2-diphenylhydrazine. The furoxans (7a,b) are accessible by pyrolysis of the respective o-nitrophenyl azides (6a,b). Compounds (10a-g) showed a comparable range of in vitro activity against Escherichia coli and Candida albicans (MIC 62.5 - 125 mu g/mL).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 15:57:24