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Titolo:
Activating separate ascending auditory pathways produces different human thalamic/cortical responses
Autore:
Waring, MD; Ponton, CW; Don, M;
Indirizzi:
House Ear Inst, Dept Electrophysiol, Los Angeles, CA 90057 USA House Ear Inst Los Angeles CA USA 90057 hysiol, Los Angeles, CA 90057 USA
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 130, anno: 1999,
pagine: 219 - 229
SICI:
0378-5955(199904)130:1-2<219:ASAAPP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN-STEM IMPLANT; MIDDLE-LATENCY RESPONSES; TEMPORAL DIPOLE MODEL; COCHLEAR NUCLEUS; EVOKED-POTENTIALS; ELECTRICAL-STIMULATION; FRONTAL COMPONENTS; N1 WAVE; LESIONS; GENERATORS;
Keywords:
auditory evoked potential; auditory brainstem implant; cochlear nucleus; electrical stimulation; human;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Waring, MD HouseSAar Inst, Dept Electrophysiol, 2100 W 3rd St, Los Angeles, CA 90057 U House Ear Inst 2100 W 3rd St Los Angeles CA USA 90057 A 90057 U
Citazione:
M.D. Waring et al., "Activating separate ascending auditory pathways produces different human thalamic/cortical responses", HEARING RES, 130(1-2), 1999, pp. 219-229

Abstract

When auditory nerve function is lost due to surgical removal of bilateral acoustic tumors in cases of neurofibromatosis type 2, a sense of hearing may be restored by means of an auditory brainstem implant (ABI), which electrically stimulates the cochlear nucleus. Electrically evoked auditory brainstem responses recorded from ABI subjects exhibit a variety of waveforms dueto the presence or absence of different components. Evidently, ABI stimulation activates different ascending auditory pathways in different individuals. This study examined whether such differences at the brainstem level areassociated with corresponding differences at higher levels. Multichannel recordings of electrically evoked middle-latency and late auditory responseswere obtained from two ABI subjects whose very different electrically evoked auditory brainstem responses represent distinct categories of waveform morphology. The waveforms of both types of response were qualitatively similar in that for each condition tested there were corresponding main peaks and troughs. Quantitatively, however, there were differences in the scalp distributions and magnitudes of all components present. One subject had distributions suggesting bilateral activation and an N1-P2 complex of large amplitude, whereas the other subject had distributions suggesting unilateral activation contralateral to the side of stimulation and an N1-P2 complex of small amplitude. The differences suggest that activation of different ascending pathways in the auditory system results in different spatial and temporal patterns of neural activity in the thalamic and/or cortical auditory areas. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:17:49