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Titolo:
Renal effects of cP450 arachidonate metabolites in the Lyon hypertensive rat
Autore:
Monneret, G; Sassard, J; Benzoni, D;
Indirizzi:
Facrancem, CNRS ESA 5014, Dept Physiol & Clin Pharmacol, F-69373 Lyon 08, F Fac Pharm Lyon France 08 pt Physiol & Clin Pharmacol, F-69373 Lyon 08, F
Titolo Testata:
FUNDAMENTAL & CLINICAL PHARMACOLOGY
fascicolo: 2, volume: 13, anno: 1999,
pagine: 226 - 231
SICI:
0767-3981(1999)13:2<226:REOCAM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
20-HYDROXYEICOSATETRAENOIC ACID; VASOCONSTRICTOR; SUBSTRATE; KIDNEY;
Keywords:
cytochrome P450; hypertensive rat; kidney;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Benzoni, D Fac Pharm, CNRS ESA 5014, Dept Physiol & Clin Pharmacol, 8 Ave Rockefeller, Fac Pharm 8 Ave Rockefeller Lyon France 08 8 Ave Rockefeller,
Citazione:
G. Monneret et al., "Renal effects of cP450 arachidonate metabolites in the Lyon hypertensive rat", FUN CL PHAR, 13(2), 1999, pp. 226-231

Abstract

This study is aimed at evaluating the influence of the cytochrome P450 arachidonate metabolites on the renal alterations exhibited by the Lyon hypertensive (LH) rat. To that purpose, kidneys were isolated from LH rats and their normotensive (LN) controls and single-pass perfused at different pressure levels before (control conditions) and after cytochrome P450 inhibition by 7-ethoxyresorufin (7-ER, 1 mu M). In control conditions, LH kidneys differed from LN ones by an increased preglomerular resistance and a blunted pressure natriuresis. 7-ER, which did not affect the function of LN kidneys, decreased the vascular resistance of LH kidneys, increased their glomerularfiltration rate but had no effect on their pressure natriuresis. These results indicate that the renal cytochrome P450 arachidonate metabolism differs between LN and LH rats and is presumably involved in the functional alterations exhibited by LH kidneys. (C) Elsevier, Paris.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 13:22:14