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Titolo:
The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells
Autore:
Kamitani, S; Asakawa, M; Shimekake, Y; Kuwasako, K; Nakahara, K; Sakata, T;
Indirizzi:
Shionogi & Co Ltd, Shionogi Inst Med Sci, Settsu, Osaka 5660022, Japan Shionogi & Co Ltd Settsu Osaka Japan 5660022 Settsu, Osaka 5660022, Japan
Titolo Testata:
FEBS LETTERS
fascicolo: 1, volume: 448, anno: 1999,
pagine: 111 - 114
SICI:
0014-5793(19990401)448:1<111:TRCIAF>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESANGIAL CELLS; HIGH-EXPRESSION; RAT; CLONING; BINDING; PEPTIDE; SYSTEM; LIGAND; GENE;
Keywords:
calcitonin gene-related peptide; calcitonin receptor-like receptor; receptor activity-modifying protein; cAMP; adrenomedullin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Sakata, T Shionogi022,o Ltd, Shionogi Inst Med Sci, 2-5-1 Mishima, Settsu,Osaka 5660 Shionogi & Co Ltd 2-5-1 Mishima Settsu Osaka Japan 5660022 5660
Citazione:
S. Kamitani et al., "The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells", FEBS LETTER, 448(1), 1999, pp. 111-114

Abstract

Adrenomedullin, a potently hypotensive peptide isolated from human pheochromocytoma, is known to elicit a rise in cAMP levels within mammalian endothelial and smooth muscle cells. Until now, however, little has been known about the adrenomedullin receptor. Recently, a group called receptor activity-modifying proteins that complex with the calcitonin receptor-like receptor, and thereby regulate its transport and ligand specificity, were identified. Here we show that mRNA for both the calcitonin receptor-like receptor and the receptor activity-modifying protein 2, but not the receptor activity-modifying protein 1 or receptor activity-modifying protein 3, are expressedin human endothelial and vascular smooth muscle cells. We also found that adrenomedullin increased cAMP levels in HeLa EBNA and 293 EBNA cells, expressing both the receptor activity-modifying protein 2 and calcitonin receptor-like receptor proteins. Thus, the receptor activity-modifying protein 2/calcitonin receptor-like receptor complex apparently serves as a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells. (C) 1999 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:23:14