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Titolo:
Cholinergic modulation of the acoustic startle response in the caudal pontine reticular nucleus of the rat
Autore:
Fendt, M; Koch, M;
Indirizzi:
Univ Tubingen, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 bingen, D-72076 Tubingen, Germany
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2, volume: 370, anno: 1999,
pagine: 101 - 107
SICI:
0014-2999(19990409)370:2<101:CMOTAS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEDUNCULOPONTINE TEGMENTAL NUCLEUS; FEAR-POTENTIATED STARTLE; PREPULSE INHIBITION; REM-SLEEP; NICOTINE; NEURONS; REFLEX; REACTIVITY; LESIONS; SYSTEM;
Keywords:
acetylcholine; acoustic startle response; carbachol; prepulse inhibition; (rat); scopolamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Fendt, M Univ Tubingen, Morgenstelle 28, D-72076 Tubingen, Germany Univ Tubingen Morgenstelle 28 Tubingen Germany D-72076 , Germany
Citazione:
M. Fendt e M. Koch, "Cholinergic modulation of the acoustic startle response in the caudal pontine reticular nucleus of the rat", EUR J PHARM, 370(2), 1999, pp. 101-107

Abstract

The startle response is a useful behavioural model to assess drug effects on sensorimotor information processing in the mammalian central nervous system. Prepulse inhibition of the acoustic startle response in rats is an operational measure for sensorimotor gating mechanisms which may be necessary for attention and response selection. The caudal pontine reticular nucleus is a key element of the pathway that mediates the acoustic startle responseand receives an inhibitory cholinergic projection that might be important for prepulse inhibition. The present study tested whether prepulse inhibition of acoustic startle is modulated by microinfusions of the muscarinic/nicotinic acetylcholine receptor agonist carbachol and of the muscarinic acetylcholine receptor antagonist scopolamine. Carbachol (0-40 nmol/0.5 mu l) dose dependently attenuated startle and enhanced prepulse inhibition. Scopolamine (0-40 nmol/0.5 mu l) dose-dependently enhanced startle and reduced prepulse inhibition at a dose of 10 nmol. Scopolamine (40 nmol) also increasedthe spontaneous motor activity of the rats. These findings lend support tothe hypothesis that muscarinic acetylcholine receptors in the caudal pontine reticular nucleus inhibit the acoustic startle response and are involvedin the mediation of prepulse inhibition of startle. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 04:02:39