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Titolo:
Effects of heart rate on arterial compliance in men
Autore:
Liang, YL; Gatzka, CD; Du, XJ; Cameron, JD; Kingwell, BA; Dart, AM;
Indirizzi:
Baker Med Res Inst, Alfred & Baker Med Unit, Prahran, Vic 3181, Australia Baker Med Res Inst Prahran Vic Australia 3181 rahran, Vic 3181, Australia La Trobe Univ, Bundoora, Vic, Australia La Trobe Univ Bundoora Vic Australia robe Univ, Bundoora, Vic, Australia Monash Univ, Dept Med, Melbourne, Vic 3004, Australia Monash Univ Melbourne Vic Australia 3004 , Melbourne, Vic 3004, Australia
Titolo Testata:
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
fascicolo: 4, volume: 26, anno: 1999,
pagine: 342 - 346
SICI:
0305-1870(199904)26:4<342:EOHROA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULSE-WAVE VELOCITY; INPUT IMPEDANCE; BLOOD-PRESSURE; DOUBLE-BLIND; HUMANS; DISTENSIBILITY; REPEATABILITY; HYPERTENSION; VALIDATION; STIFFNESS;
Keywords:
beta-adrenoceptor antagonist; arterial compliance; beta-blockers; pulse wave velocity; transoesophageal atrial pacing;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Gatzka, CD Alfred Heart Ctr, Commercial Rd, Prahran, Vic 3181, Australia Alfred Heart Ctr Commercial Rd Prahran Vic Australia 3181 ralia
Citazione:
Y.L. Liang et al., "Effects of heart rate on arterial compliance in men", CLIN EXP PH, 26(4), 1999, pp. 342-346

Abstract

1. Arterial compliance: is a major determinant of left ventricular afterload, In keeping with earlier experimental data obtained in isolated arterialsegments, it has recently been shown in the rat that arterial compliance decreases with an increase in heart rate (HR) induced by atrial pacing,2, To elucidate the potential relevance of this effect in humans, me investigated nine male volunteers (age 20-30 years; mean 26 years). Systemic arterial compliance (SAC) was measured with the diastolic area method and carotid-to-femoral and femoral-to-dorsalis pedis pulse wave velocities (PWV) were measured to determine regional changes in compliance, Heart rate was first lowered with intravenous metoprolol to 56+/-2b.p.m. and then increased by transoesophageal atrial pacing to 80 and 100 b.p.m,3, Increasing HR from 56+/-2 to 80 b.p.m, by pacing increased mean arterial pressure (MAP) from 78+/-2 to 98+/-1 mmHg (P < 0.001) and then to 102+/-2mmHg (P = NS), Systemic arterial compliance fell from 0.48+/-0.06 to 0.33+/-0.04 arbitrary compliance units (ACU; P < 0.01), carotid-to-femoral PWV increased from 6.1+/-0.3 to 6.8+/-0.4 m/s (P < 0.001) and femoral-to-dorsalis pedis PWV increased from 8.9+/-0.4 to 10.1+/-0.5 m/s (P < 0.001), Pacing at 100 b.p.m did not change MAP, but did lead to a further decrease in SAC (to 0.24+/-0.03 ACU; P < 0.05) and further increases in carotid-to-femoral (7.3+/-0.4 m/s; P = NS) and femoral-to-dorsalis pedis PWV (11.3+/-0.4 mis; P < 0.001),4, We conclude that systemic, central and peripheral compliances decrease in vivo with an increase in HR induced by atrial pacing.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 17:30:14