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Titolo:
Intercellular adhesion molecule-1 and accumulation of eosinophils in nasalpolyp tissue
Autore:
Kong, H; Dong, Z; Guo, YQ; Yang, ZQ; Bu, GX;
Indirizzi:
Norman&Bethune Univ Med Sci, Affiliated Hosp 3, Dept Otorhinolaryngol HeadNorman Bethune Univ Med Sci Changchun Peoples R China 130031 ryngol Head
Titolo Testata:
CHINESE MEDICAL JOURNAL
fascicolo: 4, volume: 112, anno: 1999,
pagine: 366 - 368
SICI:
0366-6999(199904)112:4<366:IAMAAO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Keywords:
nasal polyposis; eosinophils; intercellular adhesion molecule-1; lymphocyte function-associated antigen-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
5
Recensione:
Indirizzi per estratti:
Indirizzo: Kong, H Norman&Bethune Univ Med Sci, Affiliated Hosp 3, Dept Otorhinolaryngol Head Norman Bethune Univ Med Sci Changchun Peoples R China 130031 ead
Citazione:
H. Kong et al., "Intercellular adhesion molecule-1 and accumulation of eosinophils in nasalpolyp tissue", CHIN MED J, 112(4), 1999, pp. 366-368

Abstract

Objective To investigate the relationship between intercellular adhesion molecule-1 (ICAM-1) and the accumulation of eosinophils in nasal polyp tissue to better understand the mechanism of airway eosinophilic inflammation. Methods The expression of ICAM-1 and its natural ligand, lymphocyte function-associated antigen-1 (LFA-1), in normal nasal mucosa from 6 controls andin nasal polyp tissue from 19 patients with nasal polyposis were determined with immunohistochemistry. With dual immunohistochemistry and May-Griunwald Giemsa stain (MGG), the expression of LFA-1 and infiltrating eosinophilsin nasal polyp tissue was observed. Results The expression of ICAM-1 and LFA-1 was stronger in the nasal polyptissue than in normal nasal mucosa. There was a positive relationship between the infiltration of eosinophils and the expression of LFA-1 on eosinophils. Conclusion Accumulation of eosinophils in nasal polyp tissue is associatedwith the counter-effect between adhesion molecules and its ligand on eosinophils.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 21:13:35