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Titolo:
SYNTHESIS OF COMPLEX ETHYNYLADENOSINES USING ORGANIC TRIFLIC ENOLATESIN PALLADIUM-CATALYZED REACTIONS - POTENTIAL AGONISTS FOR THE ADENOSINE A(2) RECEPTOR
Autore:
ADAH SA; NAIR V;
Indirizzi:
UNIV IOWA,DEPT CHEM IOWA CITY IA 52242 UNIV IOWA,DEPT CHEM IOWA CITY IA 52242
Titolo Testata:
Tetrahedron
fascicolo: 20, volume: 53, anno: 1997,
pagine: 6747 - 6754
SICI:
0040-4020(1997)53:20<6747:SOCEUO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SELECTIVE AGONISTS; NUCLEOSIDES; 2-ALKYNYLADENOSINES; NUCLEOTIDES; ORGANOSTANNANES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Adah e V. Nair, "SYNTHESIS OF COMPLEX ETHYNYLADENOSINES USING ORGANIC TRIFLIC ENOLATESIN PALLADIUM-CATALYZED REACTIONS - POTENTIAL AGONISTS FOR THE ADENOSINE A(2) RECEPTOR", Tetrahedron, 53(20), 1997, pp. 6747-6754

Abstract

Many high affinity adenosine Al receptor agonists contain substituents at position 2 of the purine base. In the search for new methodology to develop C-2 substituted adenosine analogues, we have applied organic triflates in palladium-catalyzed cross-couplings that resulted in new 2-cycloalkylated ethynyladenosines. The organic triflates are derived from commercially available ketones and, when used in the cross-couplings, result generally in clean reactions with good yields. These arethe first examples of the utilization of organic triflates in palladium-catalyzed cross-coupling reactions in the synthesis of modified nucleosides. (C) 1997 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:21:20