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Titolo:
Inhibition of stem cell factor- and nerve growth factor-induced morphological change by wortmannin in mast cells
Autore:
Kim, HM; Moon, YH; An, NH;
Indirizzi:
Wonkwang Univ, Coll Pharm, Chonbuk 570749, South Korea Wonkwang Univ Chonbuk South Korea 570749 rm, Chonbuk 570749, South Korea Wonkwang Univ, Sch Med, Chonbuk 570749, South Korea Wonkwang Univ Chonbuk South Korea 570749 ed, Chonbuk 570749, South Korea
Titolo Testata:
ARCHIVES OF PHARMACAL RESEARCH
fascicolo: 2, volume: 22, anno: 1999,
pagine: 108 - 112
SICI:
0253-6269(199904)22:2<108:IOSCFA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-KIT RECEPTOR; PHOSPHATIDYLINOSITOL 3-KINASE; RAT; LIGAND; INSULIN; MICE;
Keywords:
phosphatidylinositol 3 '-kinase; stem cell factor; nerve growth factor; morphological change; rat peritoneal mast cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, HM Wonkwang Univ, Coll Pharm, Chonbuk 570749, South Korea Wonkwang Univ Chonbuk South Korea 570749 buk 570749, South Korea
Citazione:
H.M. Kim et al., "Inhibition of stem cell factor- and nerve growth factor-induced morphological change by wortmannin in mast cells", ARCH PH RES, 22(2), 1999, pp. 108-112

Abstract

Recombinant murine stem cell factor (rmSCF) or recombinant murine nerve growth factor (rmNGF) induced the morphological change of large numbers of rat peritoneal mast cells (RPMC). We investigated the role of phosphatidylinositol 3'-kinase (P13-kinase) in receptors-mediated morphological change in RPMC. Exposure of RPMC to P13-kinase inhibitor, wortmannin, before the addition of rmSCF and rmNGF antagonized those factors-induced morphological change. These results suggest that the P13-kinase is involved in the signal transduction pathway responsible for morphological change following stimulation of rmSCF and rmNGF and that wortmannin blocks these responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 18:32:01