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Titolo:
The long-term evaluation of pulmonary toxicity following isolated lung perfusion with melphalan in the rat
Autore:
Ueda, K; Sugi, K; Li, TS; Saeki, K; Nawata, S; Esato, K;
Indirizzi:
Yamaguchi Univ, Sch Med, Dept Surg 1, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ Ube Yamaguchi Japan 7558505 Ube, Yamaguchi 7558505, Japan
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 1A, volume: 19, anno: 1999,
pagine: 141 - 147
SICI:
0250-7005(199901/02)19:1A<141:TLEOPT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOXORUBICIN; METASTASES; MODEL; SARCOMA; PHARMACOKINETICS; SURVIVAL; FUDR;
Keywords:
melphalan; isolated lung perfusion; long term; toxicity; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Ueda, K Yamaguchi,Univ, Sch Med, Dept Surg 1, Koguishi 1144, Ube, Yamaguchi 7558505 Yamaguchi Univ Koguishi 1144 Ube Yamaguchi Japan 7558505 i 7558505
Citazione:
K. Ueda et al., "The long-term evaluation of pulmonary toxicity following isolated lung perfusion with melphalan in the rat", ANTICANC R, 19(1A), 1999, pp. 141-147

Abstract

The present study was conducted to evaluate the longterm pulmonary toxicity of isolated lung perfusion (ILP) with melphalan in the Int model. F344 rats were treated by ILP with 1 mg of melphalan or buffered hespan (BHE). Therats in the melphalan group were sacrificed randomly 30, 60, 90, 120, 150,and 180 days after the perfusion. Pulmonary toxicity was evaluated by pathological analysis. In the melphalan group, light and electron microscopic findings revealed perivascular and peribronchial edema, and septal thickening with cellular infiltration of the interstitial space 30 days after the perfusion but all of these changes had disappeared by 60 days. Azan stain showed a slight increase of the connective tissue at the alveolar wall in the melphalan group, but no progressive pulmonary interstitial fibrosis was observed after 180 days. Transmission electron microscopy showed minimal proliferation of the type II pneumocytes of normal appearance in the melphalan group. In conclusion, the long-term pulmonary toxicity of ILP with melphalanis acceptable; however clinical trials of this therapy need to be conducted.

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Documento generato il 01/12/20 alle ore 22:47:39