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Titolo:
Quantitative immunoprofiles of breast cancer performed by image analysis
Autore:
Querzoli, P; Albonico, G; Ferretti, S; Rinaldi, R; Magri, E; Nenci, I;
Indirizzi:
Univ0Ferrara, Dipartimento Med Sperimentale & Diagnost, Inst Pathol, I-4410 Univ Ferrara Ferrara Italy I-44100 ntale & Diagnost, Inst Pathol, I-4410 Univ Ferrara, Dept Pathol, I-44100 Ferrara, Italy Univ Ferrara Ferrara Italy I-44100 , Dept Pathol, I-44100 Ferrara, Italy
Titolo Testata:
ANALYTICAL AND QUANTITATIVE CYTOLOGY AND HISTOLOGY
fascicolo: 2, volume: 21, anno: 1999,
pagine: 151 - 160
SICI:
0884-6812(199904)21:2<151:QIOBCP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
DUCTAL CARCINOMA INSITU; HER-2/NEU ONCOGENE EXPRESSION; ESTROGEN-RECEPTOR; PROGESTERONE RECEPTORS; PROLIFERATIVE ACTIVITY; C-ERBB-2 ONCOPROTEIN; PROTEIN EXPRESSION; DNA PLOIDY; PROGNOSIS; P53;
Keywords:
breast neoplasms; image analysis; computer-assisted; quantitative immunoprofiles;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Querzoli, P Univssatoara, Dipartimento Med Sperimentale & Diagnost, Inst Pathol, Via Fo Univ Ferrara Via Fossato Mortara 64-B Ferrara Italy I-44100 o
Citazione:
P. Querzoli et al., "Quantitative immunoprofiles of breast cancer performed by image analysis", ANAL QUAN C, 21(2), 1999, pp. 151-160

Abstract

OBJECTIVE: To determine the biopathologic profiles of breast cancer for greater knowledge of tumor natural history and clinical outcome. STUDY DESIGN: In 99 in situ (ISC) and 2718 infiltrating breast carcinomas (IC), biologic markers (estrogen receptor [ER], progesterone receptor [PR] proIiferation index, cerbB-2/NEU, p53, bcl-2 and DNA ploidy) were evaluatedwith an image analysis system (CAS 200/486). In 105 mixed invasive cancerswith size less than or equal to 1 cm, a separate analysis of in situ (ISCm) and invasive component (ICm) was obtained. A clinical study of 836 invasive breast cancers Teas performed. RESULTS: Different biophenotypes were obtained: among ISCs, cribriform type exhibited biologic behavior similar to that of normal breast tissue (ER+,PR+, proliferation index [PI] low, NEU-, p53-, bcl-2+) the opposite profile was displayed by comedo type, and intermediate phenotypes were observed in noncomedo and lobular types. Comparing ISC and ISCm, PI and p53 expression had the highest levels in ISCm with respect to other groups. NEU overexpression exhibited a decreasing value from ICm to IC. Younger women (less than or equal to 40 years) with IC demonstrated a worse biologic profile (highPI, p53+, ER- and size >2 cm). In multivariate analysis, PI and NEU in node-negative patients, and NEU, PR and size in node-positive ones emerged as prognostic parameters. CONCLUSION: The results underline the importance of the quantitative biologic profile for defining tumor behavior and patient management.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 14:58:41