Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Interferon-beta inhibits Th1 responses at the dendritic cell level - Relevance to multiple sclerosis
Autore:
Bartholome, EJ; Willems, F; Crusiaux, A; Thielemans, K; Schandene, L; Goldman, M;
Indirizzi:
Free Univ Brussels, Hop Erasme, Dept Immunol, B-1070 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1070 nol, B-1070 Brussels, Belgium Free Univ Brussels, Ctr Rech Interuniv Vaccinol, B-1070 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1070 nol, B-1070 Brussels, Belgium Free Univ Brussels, Lab Physiol Immunol, Brussels, Belgium Free Univ Brussels Brussels Belgium Physiol Immunol, Brussels, Belgium
Titolo Testata:
ACTA NEUROLOGICA BELGICA
fascicolo: 1, volume: 99, anno: 1999,
pagine: 44 - 52
SICI:
0300-9009(199903)99:1<44:IITRAT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CD4(+) T-CELLS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; BLOOD MONONUCLEAR-CELLS; NECROSIS-FACTOR-ALPHA; GAMMA PRODUCTION; IN-VITRO; IFN-ALPHA; CLASS-II; COSTIMULATORY MOLECULES; LYMPHOKINE PRODUCTION;
Keywords:
interferon-beta; dendritic cells; interleukin-12; CD40; Th1/Th2; multiple sclerosis; human;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Bartholome, EJ Freesels, Brussels, Hop Erasme, Dept Immunol, 808 Route Lennik, B-1070 Brus Free Univ Brussels 808 Route Lennik Brussels Belgium B-1070
Citazione:
E.J. Bartholome et al., "Interferon-beta inhibits Th1 responses at the dendritic cell level - Relevance to multiple sclerosis", ACT NEUR BE, 99(1), 1999, pp. 44-52

Abstract

Clinical studies have demonstrated beneficial effects of interferon-beta (IFN-beta) therapy in multiple sclerosis (MS) patients. However, the mechanism of action of IFN-beta in MS remains unknown. IFN-beta has even been demonstrated to enhance isolated T cell secretion of IFN-gamma. a cytokine proven to be deleterious in MS. However, IFN-beta inhibits IFN-gamma secretion of T cells, when they are stimulated by antigen presenting cells (APC). We therefore decided to study the effects of IFN-beta on the in vitro differentiation of dendritic cells (DC), a major class of APC. First, we found thatthe addition of IFN-beta at the initiation of the differentiation did not modify DC morphology, but enhanced the expression of molecules involved in antigen presentation (HLA-DR, B7/1 and B7/2). However, DC, differentiated in the presence of IFN-beta, secreted less interleukin-12 (IL-12) both spontaneously and upon activation by CD40-ligand bearing cells. As a consequence, DC differentiated in the presence of IFN-beta induced less IFN-gamma secretion by alloreactive T cells. We conclude that the direct action of IFN-beta on DC results in inhibition of their ability to secrete IL-12 and to elicit Thelper-1 (Th-1) type responses. These results are of particular interest in MS, in which a critical role for IL-12 has recently been suggested bya number of clinical and experimental observations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 00:17:21