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Titolo:
A NOVEL HEXAAZA MACROCYCLE WITH METHYLENEPHOSPHONATE PENDANT ARMS - APOTENTIAL USEFUL CHELATE FOR BIOMEDICAL APPLICATIONS
Autore:
BLIGH SWA; CHOI N; GERALDES CFGC; KNOKE S; MCPARTLIN M; SANGANEE MJ; WOODROFFE TM;
Indirizzi:
UNIV N LONDON,SCH APPL CHEM,HOLLOWAY RD LONDON N7 8DB ENGLAND UNIV COIMBRA,FAC SCI & TECHNOL,DEPT BIOCHEM P-3049 COIMBRA PORTUGAL UNIV COIMBRA,FAC SCI & TECHNOL,CTR NEUROSCI P-3049 COIMBRA PORTUGAL
Titolo Testata:
Journal of the Chemical Society. Dalton transactions
fascicolo: 21, , anno: 1997,
pagine: 4119 - 4125
SICI:
0300-9246(1997):21<4119:ANHMWM>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NA-23 SHIFT-REAGENT; CRYSTAL-STRUCTURE; METAL-IONS; COMPLEXES; LIGANDS; PROTONATION; COORDINATION; LANTHANIDES; NMR;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
S.W.A. Bligh et al., "A NOVEL HEXAAZA MACROCYCLE WITH METHYLENEPHOSPHONATE PENDANT ARMS - APOTENTIAL USEFUL CHELATE FOR BIOMEDICAL APPLICATIONS", Journal of the Chemical Society. Dalton transactions, (21), 1997, pp. 4119-4125

Abstract

A new 18-membered hexaaza macrocyclic ligand with four pendant methylenephosphonates has been synthesized via the Mannich reaction. The protonation behaviour of this macrocycle has been followed by P-31 and H-1 NMR spectroscopy. The initial protonation pattern of the N-functionalised macrocycle is rather like its corresponding macrocyclic amine. The proton NMR spectrum of its lanthanum(III) complex in aqueous solution indicates that the complex adopts only one of the five possible conformations, either SSSS or RRRR. The crystal structure of the novel macrocyclic ligand shows an extended hydrogen-bonded structure in its solid state. The macrocycle has an unusual conformation with the pendants alternating 'up' and 'down' round the ring. The La-III complex has aunique ten-co-ordinate geometry with all pendant arms co-ordinated tothe La-III ion which is in the plane of the six macrocyclic nitrogen donors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:28:32