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Titolo:
[H-1,N-15] NUCLEAR-MAGNETIC-RESONANCE STUDIES OF [PT(DIEN)CL](- HYDROLYSIS AND REACTIONS WITH NUCLEOTIDES() (DIEN=DIETHYLENETRIAMINE) )
Autore:
GUO ZJ; CHEN Y; ZANG E; SADLER PJ;
Indirizzi:
UNIV EDINBURGH,DEPT CHEM,W MAINS RD EDINBURGH EH9 3JJ MIDLOTHIAN SCOTLAND UNIV EDINBURGH,DEPT CHEM EDINBURGH EH9 3JJ MIDLOTHIAN SCOTLAND
Titolo Testata:
Journal of the Chemical Society. Dalton transactions
fascicolo: 21, , anno: 1997,
pagine: 4107 - 4111
SICI:
0300-9246(1997):21<4107:[NSO[H>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMR-SPECTROSCOPY; GUANOSINE 5'-MONOPHOSPHATE; PLATINUM COMPLEXES; AQUEOUS-SOLUTIONS; KINETIC-ANALYSIS; DNA; OLIGONUCLEOTIDES; CIS-)PT(NH3)(2)(H2O)(2)>(2+); )PT(NH3)(3)(H2O)>(2+); PLATINATION;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
Z.J. Guo et al., "[H-1,N-15] NUCLEAR-MAGNETIC-RESONANCE STUDIES OF [PT(DIEN)CL](- HYDROLYSIS AND REACTIONS WITH NUCLEOTIDES() (DIEN=DIETHYLENETRIAMINE) )", Journal of the Chemical Society. Dalton transactions, (21), 1997, pp. 4107-4111

Abstract

The anticancer drug cisplatin is activated via hydrolysis before binding to DNA. Although [Pt(dien)Cl](+) 1 (where dien is diethylenetriamine) has been extensively used as a model for the first step in the binding of cisplatin to DNA and other biological targets, the hydrolysis behaviour of this complex is not well understood. In this work we haveused a two-dimensional [H-1,N-15] NMR approach, and have established correlations between delta(N-15) and (1)J(Pt-195-N-15) for Pt-NH2 and Pt-NH groups which are useful for assignment of resonances and identification of trans ligands, as has been previously recognised for Pt-NH3complexes. Although it has previously been suggested that the rate ofreaction of complex 1 with guanosine 5'-monophosphate is determined by the rate of hydrolysis, no NMR peaks for an aqua intermediate were detectable, and no hydrolysis of 1 alone was observed after 7 d at 298 K. This raises new questions about the mechanisms of such reactions.

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Documento generato il 30/10/20 alle ore 09:47:51