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Titolo:
EFFECT OF NEU DIFFERENTIATION FACTOR ISOFORMS ON NEONATAL OLIGODENDROCYTE FUNCTION
Autore:
RAABE TD; SUY S; WELCHER A; DEVRIES GH;
Indirizzi:
EDWARD HINES JR VET ADM HOSP,RES SERV 151,5TH AVE & ROOSEVELT RD HINES IL 60141 EDWARD HINES JR VET ADM HOSP,RES SERV 151 HINES IL 60141 LOYOLA UNIV,MED CTR,DEPT CELL BIOL NEUROBIOL & ANAT MAYWOOD IL 60153 GEORGETOWN UNIV,MED CTR,VINCENT T LOMBARDI CANC RES CTR,DEPT RADIAT MED WASHINGTON DC 20007 AMGEN INC THOUSAND OAKS CA 91320
Titolo Testata:
Journal of neuroscience research
fascicolo: 5, volume: 50, anno: 1997,
pagine: 755 - 768
SICI:
0360-4012(1997)50:5<755:EONDFI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; SCHWANN-CELL PROLIFERATION; NERVOUS-SYSTEM; SIGNAL-TRANSDUCTION; PROGENITOR CELLS; PERIPHERAL-NERVE; GLIAL-CELLS; NEUREGULINS; RECEPTORS; EXPRESSION;
Keywords:
OLIGODENDROCYTE; NEU DIFFERENTIATION FACTOR; NEUREGULIN; ERB-B RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
T.D. Raabe et al., "EFFECT OF NEU DIFFERENTIATION FACTOR ISOFORMS ON NEONATAL OLIGODENDROCYTE FUNCTION", Journal of neuroscience research, 50(5), 1997, pp. 755-768

Abstract

Previous studies have suggested that neu differentiation factor (NDF), a member of the neuregulin (NRG) family of growth factors, may regulate the development of PNS and CNS glial cells, There is limited information concerning the potential role of NDF on the development of neonatal (immature) oligodendrocytes (OLG) into adult OLG, We now report the effect of the two major isoform families of NDF (NDF alpha and NDF beta) on the development of cultured rat neonatal OLG, Immunocytochemical and western blot analyses of neonatal OLG using anti-erb-B antibodies revealed that these immature OLG express all four members of NRG (erb-B) receptors. Treatment of neonatal OLG with varying concentrations of either NDF alpha or NDF beta did not have a mitogenic effect on cultured neonatal OLG. Pretreatment of immature OLG with either of the NDF isoforms also did not influence the subsequent mitogenicity of other known OLG mitogens, However, treatment of neonatal OLG with either isoform of NDF influenced the survival of these cells by protecting the cells from apoptosis, Additionally, treatment of neonatal OLG with either NDF alpha or NDF beta resulted in more extensive process formation compared to control, non-treated OLG. (C) 1997 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:48:20