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Titolo:
TRAFFICKING OF AMINO-ACIDS BETWEEN NEURONS AND GLIA IN-VIVO - EFFECTSOF INHIBITION OF GLIAL METABOLISM BY FLUOROACETATE
Autore:
HASSEL B; BACHELARD H; JONES P; FONNUM F; SONNEWALD U;
Indirizzi:
NORWEGIAN DEF RES ESTAB,DIV ENVIRONM TOXICOL,POB 25 N-2007 KJELLER NORWAY UNIV NOTTINGHAM,DEPT PHYS,MR CTR NOTTINGHAM NG7 2RD ENGLAND SINTEF UNIMED,MR CTR TRONDHEIM NORWAY
Titolo Testata:
Journal of cerebral blood flow and metabolism
fascicolo: 11, volume: 17, anno: 1997,
pagine: 1230 - 1238
SICI:
0271-678X(1997)17:11<1230:TOABNA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE ANALYSIS; RAT-BRAIN; CEREBRAL METABOLISM; NMR-SPECTROSCOPY; C-13 NMR; GLUTAMATE TRANSPORTERS; SELECTIVE-INHIBITION; GAMMA-AMINOBUTYRATE; CULTURED ASTROCYTES; INVIVO;
Keywords:
FLUOROACETATE; GABA; GLIAL-NEURONAL INTERACTIONS; GLUTAMATE; GLUTAMINE; LACTATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
B. Hassel et al., "TRAFFICKING OF AMINO-ACIDS BETWEEN NEURONS AND GLIA IN-VIVO - EFFECTSOF INHIBITION OF GLIAL METABOLISM BY FLUOROACETATE", Journal of cerebral blood flow and metabolism, 17(11), 1997, pp. 1230-1238

Abstract

Glial-neuronal interchange of amino acids was studied by C-13 nuclearmagnetic resonance spectroscopy of brain extracts from fluoroacetate-treated mice that received [1,2-C-13]acetate and [1-C-13]glucose simultaneously. [C-13]Acetate was found to be a specific marker for glial metabolism even with thr large doses necessary for nuclear magnetic resonance spectroscopy. Fluoroacetate, 100 mg/kg, blocked the glial, but not the neuronal tricarboxylic acid cycles as seen from the C-13 labeling of glutamine, glutamate, and gamma-aminobutyric acid. Glutamine, but not citrate, was the only glial metabolite that could account for the transfer of C-13 from glia to neurons. Massive glial uptake of transmitter glutamate was indicated by the labeling of glutamine from [1-C-13]glucose in fluoroacetate-treated mice. The C-3/C-4 enrichment ratio, which indicates the degree of cycling of label, was higher in glutamine than in glutamate in the presence of fluoroacetate, suggesting that transmitter glutamate (which was converted to glutamine after release) is associated with a tricarboxylic acid cycle that turns more rapidly than the overall cerebral tricarboxylic acid cycle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 23:11:31