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Titolo:
INDUCTION OF HEPATOCYTE GROWTH-FACTOR SCATTER FACTOR BY INTERFERON-GAMMA IN HUMAN LEUKEMIA-CELLS
Autore:
GOHDA E; TAKEBE T; SOTANI T; NAKAMURA S; MINOWADA J; YAMAMOTO I;
Indirizzi:
OKAYAMA UNIV,FAC PHARMACEUT SCI,DEPT IMMUNOCHEM OKAYAMA 700 JAPAN HAYASHIBARA BIOCHEM LABS INC,FUJISAKI CELL CTR OKAYAMA JAPAN
Titolo Testata:
Journal of cellular physiology
fascicolo: 1, volume: 174, anno: 1998,
pagine: 107 - 114
SICI:
0021-9541(1998)174:1<107:IOHGSF>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SKIN FIBROBLASTS; NECROSIS-FACTOR-ALPHA; FACTOR GENE-EXPRESSION; CHRONIC HEPATITIS-B; MOLECULAR-CLONING; LIVER-REGENERATION; SEQUENCE-ANALYSIS; BINDING PROTEIN; RAT HEPATOCYTES; FACTOR-HGF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
E. Gohda et al., "INDUCTION OF HEPATOCYTE GROWTH-FACTOR SCATTER FACTOR BY INTERFERON-GAMMA IN HUMAN LEUKEMIA-CELLS", Journal of cellular physiology, 174(1), 1998, pp. 107-114

Abstract

Induction of hepatocyte growth factor/scatter factor (HGF/SF) may be one of the critical steps in organ regeneration, wound healing,and embryogenesis. We previously reported the production of HGF/SF from various human leukemia cell lines and a high level of the growth factor in blood and bone marrow plasma from patients with various types of leukemia. We determined here the effects of hematopoietic cytokines on HGF/SF production in human leukemia cell lines, KG-1, a myeloid cell line,and RPMI-8226, a B cell line. Interferon (IFN)-gamma remarkably stimulated HGF/SF production in both cell lines at concentrations of more than 0.1 or 1 IU/ml. IFN-alpha and IFN-beta were as effective as IFN-gamma in RPMI-8226 cells, but less than IFN-gamma in KG-1 cells. HGF/SF gene expression in KG-1 cells was also up-regulated by IFN-gamma. Granulocyte colony-stimulating factor (G-CSF), granulocyte/macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-5 and IL-6 had no effect on HGF/SF production in the 2 leukemia cell lines. We also determined the effects of HGF/SF inducers known for human fibroblasts on the growth factor production in leukemia cells. Out of phorbol 12-myristate 13-acetate (PMA), cholera toxin, IL-1 beta, and tumor necrosis factor (TNF)-alpha, the former three were as effective as IFN-gamma in KG-1cells, but only TNF-alpha stimulated HGF/SF production in RPMI-8226 cells, whose effect was less than those of IFN-alpha, IFN-beta, and IFN-gamma. The effect of IFN-gamma in KG-1 cells was synergistic with that of PMA. In contrast with the effect in leukemia cells, HGF/SF induction by IFN-gamma in human skin fibroblasts was much less than that by PMA or cholera toxin. These results indicated that IFN-gamma is a potent inducer of HGF/SF in human leukemia cells. This finding suggests the presence of a homeostatic control mechanism in liver regeneration and repair: hepatic injury, DNA synthesis inhibition, or apoptosis caused by IFN-gamma is subsequently overcome by cytokine-induced HGF/SF, a potent promoter of liver DNA synthesis. (C) 1998 Wiley-Liss, Inc.

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Documento generato il 04/12/20 alle ore 06:44:12