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Titolo:
PLASTICITY IN FAST SYNAPTIC INHIBITION OF ADULT OXYTOCIN NEURONS CAUSED BY SWITCH IN GABA(A) RECEPTOR SUBUNIT EXPRESSION
Autore:
BRUSSAARD AB; KITS KS; BAKER RE; WILLEMS WPA; LEYTINGVERMEULEN JW; VOORN P; SMIT AB; BICKNELL RJ; HERBISON AE;
Indirizzi:
VRIJE UNIV AMSTERDAM,NEUROSCI RES INST,MEMBRANE PHYSIOL SECT,DE BOELELAAN 1087 NL-1081 HV AMSTERDAM NETHERLANDS VRIJE UNIV AMSTERDAM,NEUROSCI RES INST,MOL NEUROBIOL SECT NL-1081 HV AMSTERDAM NETHERLANDS VRIJE UNIV AMSTERDAM,NEUROSCI RES INST,DEPT ANAT NL-1081 HV AMSTERDAMNETHERLANDS BABRAHAM INST,NEUROENDOCRINOL LAB CAMBRIDGE CB2 4AT ENGLAND
Titolo Testata:
Neuron
fascicolo: 5, volume: 19, anno: 1997,
pagine: 1103 - 1114
SICI:
0896-6273(1997)19:5<1103:PIFSIO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPOTHALAMIC MAGNOCELLULAR NEURONS; A RECEPTOR; MESSENGER-RNAS; RAT-BRAIN; ANTISENSE OLIGONUCLEOTIDES; POSTNATAL-DEVELOPMENT; ALPHA-SUBUNITS; GABA(A)-RECEPTOR SUBTYPES; POSTSYNAPTIC CURRENTS; FUNCTIONAL-PROPERTIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
68
Recensione:
Indirizzi per estratti:
Citazione:
A.B. Brussaard et al., "PLASTICITY IN FAST SYNAPTIC INHIBITION OF ADULT OXYTOCIN NEURONS CAUSED BY SWITCH IN GABA(A) RECEPTOR SUBUNIT EXPRESSION", Neuron, 19(5), 1997, pp. 1103-1114

Abstract

We found that magnocellular oxytocin neurons in adult female rats exhibit an endogenous GABA(A) receptor subunit switch around parturition:a decrease in alpha 1:alpha 2 subunit mRNA ratio correlated with a decrease in allopregnanolone potentiation and increase in decay time constant of the GABA(A) receptor-mediated IPSCs in these cells. The causal relationship between changes in alpha 1:alpha 2 mRNA ratio and the ion channel kinetics was confirmed using in vitro antisense deletion. Further, GABA(A) receptors exhibited a tonic inhibitory influence upon oxytocin release in vivo, and allopregnanolone helped to restrain oxytocin neuron in vitro firing only before parturition, when the alpha 1:alpha 2 subunit mRNA ratio was still high. Such observations provide evidence for the physiological significance of GABA(A) receptor subunitheterogeneity and plasticity in the adult brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:37:50