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Titolo:
DIFFERENTIAL RESPONSIVENESS TO CONTRACTILE AGENTS OF ISOLATED SMOOTH-MUSCLE CELLS FROM HUMAN COLONS AS A FUNCTION OF AGE AND INFLAMMATION
Autore:
BOYER JC; GUITTON C; PIGNODEL C; CUQ P; MOUSSU P; POUDEROUX P; CHRISTEN MO; BALMES JL; BALI JP;
Indirizzi:
CHU CAREMEAU,UNITE FONCTIONNELLE EXPLORAT FIBRE LISSE,RUE PROF ROBERTDEBRE F-30006 NIMES FRANCE CHU CAREMEAU,UNITE FONCTIONNELLE EXPLORAT FIBRE LISSE F-30006 NIMES FRANCE CHU CAREMEAU,ANAT PATHOL LAB F-30006 NIMES FRANCE FAC PHARM MONTPELLIER,BIOCHIM MEMBRANES LAB,INSERM CJF9207 MONTPELLIER FRANCE SOLVAY PHARMA SURESNES FRANCE
Titolo Testata:
Digestive diseases and sciences
fascicolo: 11, volume: 42, anno: 1997,
pagine: 2190 - 2196
SICI:
0163-2116(1997)42:11<2190:DRTCAO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCARINIC RECEPTOR SUBTYPES; NEMATODE-INFECTED RAT; EXPERIMENTAL COLITIS; LONGITUDINAL MUSCLE; ULCERATIVE-COLITIS; CIGARETTE-SMOKING; CIRCULAR MUSCLE; CROHNS-DISEASE; BOWEL-DISEASE; RELAXATION;
Keywords:
SMOOTH MUSCLE CELLS; COLON; CONTRACTION; CCK; MUSCARINIC AGONISTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
J.C. Boyer et al., "DIFFERENTIAL RESPONSIVENESS TO CONTRACTILE AGENTS OF ISOLATED SMOOTH-MUSCLE CELLS FROM HUMAN COLONS AS A FUNCTION OF AGE AND INFLAMMATION", Digestive diseases and sciences, 42(11), 1997, pp. 2190-2196

Abstract

To study the involvement of age and inflammation in motor colonic activity in man, contractile responses to CCK, carbachol, and KCl of isolated colonic smooth muscle cells (SMC) from normal and inflamed human colons were evaluated; the incidence of sex and smoking on contractionwas also analyzed. Contractile responses to the three agonists were significantly lower in tissues with a low degree of inflammation than in tissues with high level of inflammation or normal tissues. This reduction in cell responsiveness appears to be nonspecific and nonreceptormediated. A positive correlation of the contractile responses to the three stimulants with the age of patients was observed. In contrast, no association was found between sex, smoking, and cell contraction. Inconclusion, contractions of SMC due to CCK, carbachol, and KCl were significantly modified during life; inflammation of the colon led to a loss of SMC responsiveness.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:59:16