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Titolo:
PUMP-LEAK PARALLELISM IN SODIUM-ABSORBING EPITHELIA - THE ROLE OF ATP-REGULATED POTASSIUM CHANNELS
Autore:
SCHULTZ SG;
Indirizzi:
UNIV TEXAS,SCH MED,DEPT INTEGRAT BIOL,POB 20708 HOUSTON TX 77225
Titolo Testata:
The Journal of experimental zoology
fascicolo: 5, volume: 279, anno: 1997,
pagine: 476 - 483
SICI:
0022-104X(1997)279:5<476:PPISE->2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECTURUS SMALL-INTESTINE; PROXIMAL CONVOLUTED TUBULE; COUPLED SUGAR-TRANSPORT; BASOLATERAL MEMBRANES; K+ CHANNEL; RESPIRATORY CELLS; THYROID-HORMONE; RAT-LIVER; FROG-SKIN; NA+;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
S.G. Schultz, "PUMP-LEAK PARALLELISM IN SODIUM-ABSORBING EPITHELIA - THE ROLE OF ATP-REGULATED POTASSIUM CHANNELS", The Journal of experimental zoology, 279(5), 1997, pp. 476-483

Abstract

In all Na+-absorbing and Cl--secreting epithelia, an increase in the activity of the Na+,K+-pump at the basolateral membrane is accompaniedby an increase in the K+ conductance of that barrier and vice versa. We have recently identified an ATP-regulated K+ channel, K-(ATP), in basolateral membrane vesicles isolated from Necturus maculosa small intestinal epithelial cells that could be responsible for this parallelism between pump activity and leak. Thus, an increase in pump activity would result in a decrease in local ATP activity and an increase in local ADP activity and, in turn, an increase in the open-probabilty of the channel whereas a decrease in pump activity would have the opposite effect. Further, the likelihood that the number of pumps far exceeds the number of leaks per unit area of membrane suggests that the ATP andADP activities that influence K-(ATP) channel activity may differ markedly from the ''bulk'' cytoplasmic values. (C) 1997 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 11:43:20