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Titolo:
CLINICAL-TRIALS IN THROMBOLYTIC THERAPY .1. OUTCOME MARKERS THAT GO BEYOND MORTALITY REDUCTION
Autore:
STRINGER KA;
Indirizzi:
UNIV COLORADO,HLTH SCI CTR,SCH PHARM,C238,4200 E 9TH AVE DENVER CO 80262
Titolo Testata:
American journal of health-system pharmacy
, volume: 54, anno: 1997, supplemento:, 1
pagine: 23 - 26
SICI:
1079-2082(1997)54:<23:CITT.O>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; ST SEGMENT ELEVATION; STRONG PREDICTOR; RESOLUTION; EXTENT;
Keywords:
CLINICAL STUDIES; DRUGS, CLINICAL EFFECTIVENESS; ECONOMICS; MORTALITY; MYOCARDIAL INFARCTION; OUTCOMES; THROMBOLYTIC AGENTS;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
K.A. Stringer, "CLINICAL-TRIALS IN THROMBOLYTIC THERAPY .1. OUTCOME MARKERS THAT GO BEYOND MORTALITY REDUCTION", American journal of health-system pharmacy, 54, 1997, pp. 23-26

Abstract

The use of outcome markers other than mortality reduction alone for evaluating thrombolytic agents in patients with acute myocardial infarction (AMI) is discussed. Mortality has been a primary endpoint in clinical trials evaluating thrombolytic agents for treatment of AMI. However, differences in mortality rates among thrombolytics are 1% or less and require tens of thousands of patients to detect. Broadening the endpoints studied of reperfusion, such as early resolution of ST segmentelevation; and resolution of chest pain. Available longterm data showthat the mortality benefit from alteplase is sustained over time and is correlated with enzymatically determined infarct size, left ventricular function, the number of diseased vessels, and Thrombolysis in Myocardial Infarction flow grade at the time of discharge from the hospital. Clinicians must also consider risk factors for stroke. Outcome measures other than mortality alone may help in determining which thrombolytic agent is most effective clinically and in financial decision-making without requiring large, expensive trials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:40:59