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Titolo:
STRATEGIES FOR THE MANAGEMENT OF ACUTE MYOCARDIAL-INFARCTION - SELECTING PATIENTS FOR THROMBOLYTIC THERAPY
Autore:
TALBERT RL;
Indirizzi:
UNIV TEXAS,HLTH SCI CTR,DEPT MED,7703 FLOYD COURT SAN ANTONIO TX 78284 UNIV TEXAS,HLTH SCI CTR,DEPT PHARMACOL SAN ANTONIO TX 78284 UNIV TEXAS,COLL PHARM AUSTIN TX 78712
Titolo Testata:
American journal of health-system pharmacy
, volume: 54, anno: 1997, supplemento:, 1
pagine: 9 - 16
SICI:
1079-2082(1997)54:<9:SFTMOA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC TROPONIN-T; CASE-FATALITY RATES; RANDOMIZED TRIAL; MORTALITY; REPERFUSION; ANGIOPLASTY; PREVALENCE; DIAGNOSIS; ISCHEMIA; DEATH;
Keywords:
ANGIOPLASTY; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANTICOAGULANTS; ASPIRIN; DISEASE MANAGEMENT; HEPARIN; MYOCARDIAL INFARCTION; PATIENTS; PLATELET AGGREGATION INHIBITORS; RATIONAL THERAPY; SYMPATHOLYTIC AGENTS; THROMBOLYTIC AGENTS;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
R.L. Talbert, "STRATEGIES FOR THE MANAGEMENT OF ACUTE MYOCARDIAL-INFARCTION - SELECTING PATIENTS FOR THROMBOLYTIC THERAPY", American journal of health-system pharmacy, 54, 1997, pp. 9-16

Abstract

Strategies for managing acute myocardial infarction (AMI), with a focus on thrombolytics, are reviewed. Revised guidelines published by theAmerican College of Cardiology and the American Heart Association strongly recommend the use of thrombolytic therapy in carefully selected patients to promote reperfusion of ischemic myocardium. Thrombolytics reduce in-hospital mortality, and the mortality benefit is maintained for at least one year. Which patients are the best candidates for thrombolytics has been debated; variables that have been analyzed include infarct location, time after onset of symptoms, age, sex, blood pressure, and prior AMI. Clinicians should be thoroughly familiar with the absolute and relative contraindications to thrombolytic therapy to minimize potential hemorrhagic complications. The diagnosis of AMI should be clearly established. All patients should receive thrombolytic therapy ii they arrive for treatment within 12 hours of the inset of symptoms of AMI and have appropriate ECG changes. Aspirin should be given toall patients, and beta-blockers should also be given if there are no contraindications. Heparin may be given as antithrcmbotic therapy in patients not receiving thrombolytics or as adjuvant therapy in those receiving thrombolytics. Other adjuvant treatments, notably angiotensin-converting-enzyme inhibitors, are used as indicated. Primary angioplasty may have a role in selected patients. Long-term interventions are intended to pre vent recurrence of AMI. Thrombolytic therapy can substantially improve survival and function in patients with AMI, especiallywhen it is given within six hours of the onset of symptoms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:42:03