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Titolo:
ACTIONS OF KAINATE AND AMPA SELECTIVE GLUTAMATE-RECEPTOR LIGANDS ON NOCICEPTIVE PROCESSING IN THE SPINAL-CORD
Autore:
PROCTER MJ; HOUGHTON AK; FABER ESL; CHIZH BA; ORNSTEIN PL; LODGE D; HEADLEY PM;
Indirizzi:
UNIV BRISTOL,SCH MED SCI,DEPT PHYSIOL,UNIV WALK BRISTOL BS8 1TD AVON ENGLAND UNIV BRISTOL,SCH MED SCI,DEPT PHYSIOL BRISTOL BS8 1TD AVON ENGLAND ELI LILLY & CO,LILLY CORP CTR INDIANAPOLIS IN 46285
Titolo Testata:
Neuropharmacology
fascicolo: 10-11, volume: 37, anno: 1998,
pagine: 1287 - 1297
SICI:
0028-3908(1998)37:10-11<1287:AOKAAS>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONCANAVALIN-A; IN-VITRO; RAT; DESENSITIZATION; REFLEXES; NMDA; 2,3-BENZODIAZEPINES; CYCLOTHIAZIDE; TRANSMISSION; ANTAGONISTS;
Keywords:
AMPA RECEPTORS; GLUR5; GLUTAMATE RECEPTORS; KAINATE RECEPTORS; NOCICEPTION; SPINAL CORD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
M.J. Procter et al., "ACTIONS OF KAINATE AND AMPA SELECTIVE GLUTAMATE-RECEPTOR LIGANDS ON NOCICEPTIVE PROCESSING IN THE SPINAL-CORD", Neuropharmacology, 37(10-11), 1998, pp. 1287-1297

Abstract

Kainate receptors expressing the GluR5 subunit of glutamate receptor are present at high levels on small diameter primary afferent neuronesthat are considered to mediate nociceptive inputs. This suggests thatGluR5 selective ligands could be novel analgesic agents. The role of kainate receptors on C fibre primary afferents has therefore been probed using three compounds that are selective for homomeric GluR5 receptors. The agonist, ATPA, and the antagonists, LY294486 and LY382884, have been tested in four models of nociception: responses evoked by noxious stimulation of the periphery have been recorded electrophysiologically (1) from hemisected spinal cords from neonatal rats in vitro, (2)from single motor units in adult rats in vivo, (3) from dorsal horn neurones in adult rats in vivo, and (4) in hotplate tests with conscious mice. In some protocols comparisons were made with the AMPA selective antagonist GYKI 53655. The agonist ATPA reduced nociceptive reflexesin vitro, but failed to have effects in vivo. In all tests, the GluR5antagonists reduced nociceptive responses but only at doses that alsoaffected responses to exogenous AMPA. The AMPA antagonist reduced nociceptive responses at doses causing relatively greater reductions of responses to exogenous AMPA. The results indicate that GluR5 selective ligands do reduce spinal nociceptive responses, but they are not strongly analgesic under these conditions of acute nociception. (C) 1998 Elsevier Science Ltd. All rights reserved.

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Documento generato il 03/07/20 alle ore 01:13:02