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Titolo:
RESIDUAL EFFECTS OF EVENING AND MIDDLE-OF-THE-NIGHT ADMINISTRATION OFZALEPLON-10 AND ZALEPLON-20 MG ON MEMORY AND ACTUAL DRIVING PERFORMANCE
Autore:
VERMEEREN A; DANJOU PE; OHANLON JF;
Indirizzi:
MAASTRICHT UNIV,DEPT PSYCHOL,BRAIN & BEHAV INST,EXPT PSYCHOPHARMACOL UNIT,POB 616 NL-6200 MD MAASTRICHT NETHERLANDS WYETH AYERST RES,EUROPEAN CLIN R&D PARIS FRANCE
Titolo Testata:
Human psychopharmacology
, volume: 13, anno: 1998, supplemento:, 2
pagine: 98 - 107
SICI:
0885-6222(1998)13:<98:REOEAM>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEALTHY-VOLUNTEERS; PLACEBO; PSYCHOMOTOR; ZOPICLONE; BENZODIAZEPINES; LORAZEPAM; HYPNOTICS; TRIAZOLAM; SINGLE;
Keywords:
ZALEPLON; ZOPICLONE; HYPNOTICS; HEALTHY VOLUNTEERS; DRIVING; MEMORY; SDLP; SLEEP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
A. Vermeeren et al., "RESIDUAL EFFECTS OF EVENING AND MIDDLE-OF-THE-NIGHT ADMINISTRATION OFZALEPLON-10 AND ZALEPLON-20 MG ON MEMORY AND ACTUAL DRIVING PERFORMANCE", Human psychopharmacology, 13, 1998, pp. 98-107

Abstract

Zaleplon, a new pyrazolopyrimidine hypnotic, possesses an unusually short elimination half-life (ca 1 h). This study was conducted to determine whether middle-of-the-night administration of zaleplon affects memory or driving performance the following morning. Twenty-eight healthy volunteers participated in a double-blind, 7-way, crossover study. They ingested capsules twice on each treatment night; once before initiating sleep and again after being briefly awakened 5 h later. Treatments were: placebo at both times, zaleplon 10 or 20 mg, or zopiclone 7.5mg followed by placebo, or the same in reverse order. Subjects arose 3 h after the second dose. One hour later, sleep quality and mood wereassessed by questionnaires and balance and memory in a test battery. A standardized actual driving test was undertaken between 5 and 6 h after the second dose. All drugs similarly improved sleep quality, but only zopiclone hindered awakening. Evening zaleplon doses were without significant effects. Late-night zaleplon had minor effects in one memory test. Evening zopiclone shared these effects and also significantlyimpaired driving performance. Late-night zopiclone's effects were significant in every test. Its effects on driving were severe. The results suggest that zaleplon 10 mg certainly, and 20 mg probably, can be taken at bedtime or later in the night,up to 5 h before driving with little risk of serious impairment. (C) 1998 John Wiley & Sons, Ltd.

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Documento generato il 04/12/20 alle ore 11:49:23