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Titolo:
CLINICAL-STUDIES ON 3 CASES OF THE INTERVAL FORM OF CARBON-MONOXIDE POISONING - SERIAL PROTON MAGNETIC-RESONANCE SPECTROSCOPY AS A PROGNOSTIC PREDICTOR
Autore:
SAKAMOTO K; MURATA T; OMORI M; KIMURA H; NISHIO M; MURATA I; KOSHINO Y; ITOH S; ISHII Y; ISAKI K;
Indirizzi:
FUKUI MED UNIV,DEPT NEUROPSYCHIAT,23 SHIMOAIZUKI,MATSUOKA CHO FUKUI 9101193 JAPAN FUKUI MED UNIV,DEPT RADIOL FUKUI JAPAN KANAZAWA UNIV,SCH MED,DEPT NEUROPSYCHIAT KANAZAWA ISHIKAWA 920 JAPAN
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 3, volume: 83, anno: 1998,
pagine: 179 - 192
SICI:
0925-4927(1998)83:3<179:CO3COT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MR SPECTROSCOPY; LOCALIZED PROTON; COMPUTED-TOMOGRAPHY; METABOLIC CHANGES; WHITE-MATTER; BRAIN; LESIONS; INTOXICATION; SEQUELAE; TOXICITY;
Keywords:
INTERVAL FORM OF CARBON MONOXIDE POISONING; MAGNETIC RESONANCE SPECTROSCOPY (MRS); LACTATE; N-ACETYLASPARTATE; CHOLINE; AKINETIC MUTISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
K. Sakamoto et al., "CLINICAL-STUDIES ON 3 CASES OF THE INTERVAL FORM OF CARBON-MONOXIDE POISONING - SERIAL PROTON MAGNETIC-RESONANCE SPECTROSCOPY AS A PROGNOSTIC PREDICTOR", PSYCHIATRY RESEARCH-NEUROIMAGING, 83(3), 1998, pp. 179-192

Abstract

Three patients with the interval form of carbon monoxide (CO) poisoning were studied for associations between their clinical courses and serial changes on: (1) MRI; (2) EEG; (3) single photon emission computedtomography with N-isopropyl-p-[I-123]iodoamphetamine ([I-123]IMP SPECT); and (4) proton magnetic resonance spectroscopy ([H-1]MRS) to evaluate their usefulness as prognostic predictors. A hyperintense area on MRI T-2-weighted images and a hypointense area on T-1-weighted images,appearing in the deep white matter, persisted for a prolonged period even after improvement of the clinical symptoms, and did not become anaccurate indicator of clinical evaluation or prognosis. [H-1]MRS studies with the volume of interest set in the frontal lobe white matter revealed increases in choline-containing compounds, and reductions of N-acetylaspartate in all cases. These findings normalized in one subclinical case over time. Distinctive findings in the severe cases included increased lactate in two cases showing akinetic mutism, with a difference in prognosis noted according to the degree and period of persistence of this increase. EEG findings were relatively well correlated with clinical symptoms in the early period, with a good correlation no longer consistent after a certain period was exceeded. [I-123]IMP SPECTfindings did not always reflect clinical symptomatology either. Theseresults indicate that [H-1]MRS is the most useful indicator in the clinical evaluation of patients with the interval form of CO poisoning. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 02/04/20 alle ore 13:04:06