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Titolo:
RECRUITMENT OF HEPATIC NK CELLS BY IL-12 IS DEPENDENT ON IFN-GAMMA AND VCAM-1 AND IS RAPIDLY DOWN-REGULATED BY A MECHANISM INVOLVING T-CELLS AND EXPRESSION OF FAS
Autore:
FOGLER WE; VOLKER K; WATANABE M; WIGGINTON JM; ROESSLER P; BRUNDA MJ; ORTALDO JR; WILTROUT RH;
Indirizzi:
NCI,EXPT IMMUNOL LAB,DIV BASIC SCI,FREDERICK CANC RES & DEV CTR,BLDG 560,ROOM 31-93 FREDERICK MD 21702 NCI,EXPT IMMUNOL LAB,DIV BASIC SCI,FREDERICK CANC RES & DEV CTR FREDERICK MD 21702 NCI,SCI APPLICAT INT CORP,FREDERICK CANC RES & DEV CTR FREDERICK MD 21702 NIH,PEDIAT ONCOL BRANCH BETHESDA MD 20892 HOFFMANN LA ROCHE INC,DEPT ONCOL NUTLEY NJ 07110
Titolo Testata:
The Journal of immunology (1950)
fascicolo: 11, volume: 161, anno: 1998,
pagine: 6014 - 6021
SICI:
0022-1767(1998)161:11<6014:ROHNCB>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; LARGE GRANULAR LYMPHOCYTES; INTERFERON-GAMMA; STIMULATORY FACTOR; IN-VIVO; RESPONSE MODIFIERS; VIRAL-INFECTIONS; IMMUNE PRIVILEGE; INTERLEUKIN-12; LIGAND;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
W.E. Fogler et al., "RECRUITMENT OF HEPATIC NK CELLS BY IL-12 IS DEPENDENT ON IFN-GAMMA AND VCAM-1 AND IS RAPIDLY DOWN-REGULATED BY A MECHANISM INVOLVING T-CELLS AND EXPRESSION OF FAS", The Journal of immunology (1950), 161(11), 1998, pp. 6014-6021

Abstract

NK cells have been shown to be important antitumor or antiviral effector cells in the liver. In the present study we have examined the factors that regulate the initial recruitment and subsequent fate of hepatic NK and T cells in mice treated with IL-12 or IL-2. Daily administration of IL-12 caused a rapid initial increase in NK cells followed by a subsequent decrease that coincided with an accumulation of T cells, The recruitment of hepatic Mt cells by IL-12, but not the subsequent Tcell infiltrate, was abrogated in IFN-gamma(-/-) mice. In contrast, daily administration of IL-2 caused a sustained increase in liver-associated NK cells that was not diminished in IFN-gamma(-/-) mice, The IL-12-induced recruitment in both hepatic NK and T cells was abrogated byin vivo treatment with anti-VCAM-1 mAbs, while treatment with anti-ICAM-1 Abs decreased only the recruitment of T cells in the IL-12-treated mice, The rapid loss of newly recruited hepatic NK cells in IL-12-treated mice did not occur in SCID mice or in B.MRL-Fas(lpr) (Fas(-)) and B6Smn.C3H-Fasl(gld) (FasL(-)) mutant mice, suggesting that T cells can actively eliminate hepatic Mt cells through a Fas-dependent mechanism, These Endings also imply that during the endogenous innate immune response to infectious agents or tumors or in the host response induced by cytokine therapies, the biologic effects of NK cells may be limited by T cell-mediated effects.

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Documento generato il 30/09/20 alle ore 08:41:31